223560-31-4

Basic information

• Product Name: N-[2-hydroxy-1-(1-hydroxymethyl)ethyl]phenylacetamide
• Synonyms: N-[2-hydroxy-1-(1-hydroxymethyl)ethyl]phenylacetamide
• CAS NO: 223560-31-4
• Molecular Weight: 209.245
• Mol File: 223560-31-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[2-hydroxy-1-(1-hydroxymethyl)ethyl]phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-hydroxy-1-(1-hydroxymethyl)ethyl]phenylacetamide(223560-31-4)
• EPA Substance Registry System: N-[2-hydroxy-1-(1-hydroxymethyl)ethyl]phenylacetamide(223560-31-4)

Safety Data

• Hazardous Substances Data: 223560-31-4(Hazardous Substances Data)

Upstream product

• 65415-04-5 methyl (2-phenylacetyl)-L-serinate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 534-03-2 serinol 

Downstream Products

• 866612-77-3 N-[2-(2-oxo-ethyl)-[1,3]dioxan-5-yl]-2-phenyl-acetamide 
• 866612-72-8 N-[2-(2,2-dimethoxy-ethyl)-[1,3]dioxan-5-yl]-2-phenyl-acetamide 
• 943655-74-1 cis-N-[2-((E)-phenylvinyl)-4-methyl-1,3-dioxan-5-yl]phenylacetamide 
• 943655-76-3 N-[trans-2-((E)-styryl)-1,3-dioxan-5-yl]phenylacetamide 
• 943655-68-3 trans-N-[2-(3'-nitrophenyl)-1,3-dioxan-5-yl]phenylacetamide 
• 943655-67-2 trans-N-[2-(4'-nitrophenyl)-1,3-dioxan-5-yl]phenylacetamide 
• 943655-66-1 trans-N-[2-(4'-chlorophenyl)-1,3-dioxan-5-yl]phenylacetamide 
• 943655-65-0 trans-N-[2-(4'-methylphenyl)-1,3-dioxan-5-yl]phenylacetamide 
• 943655-64-9 N-(trans-2-phenyl-1,3-dioxan-5-yl)phenylacetamide 

Relevant articles and documents

Amidation of esters with amino alcohols using organobase catalysis

A catalytic protocol for the base-mediated amidation of unactivated esters with amino alcohol derivatives is reported. Investigations into mechanistic aspects of the process indicate that the reaction involves an initial transesterification, followed by an intramolecular rearrangement. The reaction is highly general in nature and can be extended to include the synthesis of oxazolidinone systems through use of dimethyl carbonate.

Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes

A new series of optically pure 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes were designed and synthesized via a chemo-enzymatic combined method to develop new chemoprevention agents. Twenty-four of newly synthesized compounds significantly inhibited xylene-induced rat ear edema and exhibited comparable or better anti-inflammatory activities than the reference drug aspirin. Treatment of these anti-inflammatory agents did not prolong the tail bleeding time in rat. In addition, 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes exhibited good membrane permeability based on in vitro Caco-2 cell monolayer permeability assay. Furthermore, some preliminary structure-activity relationships were further analyzed among these compounds. Taken together, 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes may represent a new class of anti-inflammatory drugs with safer pharmacological profile.