223762-69-4

Basic information

• Product Name: 1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE
• Synonyms: 1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE;5-(1H-Imidazol-1-yl)-m-xylene;1-(3,5-dimethylphenyl)imidazole
• CAS NO: 223762-69-4
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Product Categories: pharmacetical
• Mol File: 223762-69-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 323.831°C at 760 mmHg
• Flash Point: 149.648°C
• Appearance: /
• Density: 1.035g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE(223762-69-4)
• EPA Substance Registry System: 1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE(223762-69-4)

Safety Data

• Hazardous Substances Data: 223762-69-4(Hazardous Substances Data)

Usage

General Description

1-(3,5-DIMETHYLPHENYL)-1H-IMIDAZOLE is a chemical compound with the molecular formula C11H12N2. It is an imidazole derivative, which is a type of organic compound containing a five-membered ring with two nitrogen atoms. This particular compound has a 3,5-dimethylphenyl group attached to the imidazole ring, giving it specific chemical and biological properties. It is commonly used in the field of pharmaceuticals, as it can act as a ligand or substrate in various biological processes. Additionally, it has been studied for its potential antibacterial, antifungal, and anti-cancer properties, making it a topic of interest for researchers in the medical and chemical fields.

InChI:InChI=1/C11H12N2/c1-9-5-10(2)7-11(6-9)13-4-3-12-8-13/h3-8H,1-2H3

Upstream product

• 288-32-4 1H-imidazole 
• 556-96-7 5-bromo-1,3-xylene 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 50-00-0 formaldehyd 
• 131543-46-9 Glyoxal 
• 108-69-0 3,5-dimethylaminoaniline 
• 172975-69-8 3,5-dimethylphenyl boronic acid 

Downstream Products

• 1263043-84-0 C₃₉H₄₅N₇ 

Relevant articles and documents

A waste-minimized protocol for copper-catalyzed Ullmann-type reaction in a biomass derived furfuryl alcohol/water azeotrope

We report the use of biomass-derived furfuryl alcohol as an effective bidentate ligand able to promote the Ullmann-type copper-catalyzed coupling of aryl halides with heteroaromatic or aliphatic amines. Furfuryl alcohol (FA) can be mixed with water to form the corresponding azeotrope (20 wt% of FA) and therefore can be easily recovered and reused. This protocol is efficiently applied to substrates with various electronic nature and affords the expected products (27 examples) in generally good to excellent yields. It has also been demonstrated that the protocol is both chemically and environmentally effective as the azeotropic mixture can be easily and almost quantitatively recovered at the end of the process.

Copper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions

A simple, inexpensive and ligand-free copper-catalysed N-arylation of pyrrole with aryl iodides has been developed giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air.

Efficient copper-catalyzed ullmann reaction of aryl bromides with imidazoles in water promoted by a pH-Responsive ligand

A series of 1,10-phenanthroline derivatives were used as supporting ligands for copper-catalyzed Ullmann reaction in neat water. The catalytic system based on 4,7-dihydroxy-1,10-phenanthroline has demonstrated the promising catalytic performances for aryl