223776-49-6 Usage
Description
(11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-androsta-1,4-dien-3-one is a complex organic compound with a unique molecular structure. It is characterized by the presence of a 9-chloro substituent, a 17-(2,2-dioxido-5H-1,2-oxathiol-4-yl) group, and a 17-[(2-furanylcarbonyl)oxy] moiety. Additionally, it features an 11-hydroxy and a 16-methyl group attached to the androsta-1,4-dien-3-one core. (11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-androsta-1,4-dien-3-one is an impurity of Mometasone Furoate, a pharmaceutical agent.
Uses
Used in Pharmaceutical Industry:
(11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-androsta-1,4-dien-3-one is used as an impurity in Mometasone Furoate, a topical corticosteroid. It serves as an anti-inflammatory agent, helping to reduce inflammation and alleviate symptoms associated with various skin conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 223776-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,7,7 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 223776-49:
(8*2)+(7*2)+(6*3)+(5*7)+(4*7)+(3*6)+(2*4)+(1*9)=146
146 % 10 = 6
So 223776-49-6 is a valid CAS Registry Number.
223776-49-6Relevant articles and documents
Unusual hydroxy-γ-sultone byproducts of steroid 21- methanesulfonylation. An efficient synthesis of mometasone 17-furoate (Sch 32088)
Draper, Richard W.,Bin, Hu,McPhail, Andrew T.,Puar, Mohindar S.,Vater, Eugene J.,Weber, Lois
, p. 3355 - 3364 (1999)
An efficient two stage synthesis of the steroid anti-inflammatory agent mometasone 17-furoate (Sch 32088) 4 from 17α,21-dihydroxy-16α-methyl- 9β,11β-oxidopregna-1,4-diene-3,20-dione 6 is described and the structures of unusual δ-hydroxy-γ-sultone byproducts of 4-dimethylaminopyridine catalyzed methanesulfonylation of 21-hydroxy-20-ketosteroids are deduced.
