223797-65-7

Basic information

• Product Name: 3-Chloro-5-ethoxypyridine
• Synonyms: 3-Chloro-5-ethoxypyridine
• CAS NO: 223797-65-7
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.6
• Mol File: 223797-65-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloro-5-ethoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-ethoxypyridine(223797-65-7)
• EPA Substance Registry System: 3-Chloro-5-ethoxypyridine(223797-65-7)

Safety Data

• Hazardous Substances Data: 223797-65-7(Hazardous Substances Data)

Usage

General Description

3-Chloro-5-ethoxypyridine is a compound composed of a pyridine ring with a chlorine atom at the 3-position and an ethoxy group at the 5-position. It is a pale yellow liquid and has a molecular formula of C7H8ClNO. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic molecules. It is also a valuable building block in the production of various heterocyclic compounds. 3-Chloro-5-ethoxypyridine is known for its versatile reactivity and is used in a variety of chemical reactions to create new compounds with diverse applications. However, it should be handled with caution due to its potential to cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 141-52-6 sodium ethanolate 
• 74115-12-1 5-chloropyridin-3-ol 
• 75-03-6 ethyl iodide 

Downstream Products

• 223795-11-7 1-(5-ethoxy-pyridin-3-yl)-piperazine 
• 51468-00-9 5-ethoxy-pyridin-3-ylamine 

Relevant articles and documents

Regioselective Amination or Alkoxylation of Halogenated Amino-, Thio- or Alkoxypyridines via Pyridyne Intermediates

The treatment of 3-halopyridines (Cl, Br) bearing an R-substituent in position 2 (R = OEt, NEt2, N-piperidyl, or SEt) or in position 5 (R = OMe, OEt, SEt, NMe2, NEt2, or aryl) with KHMDS and an amine at 25 C for 12 hours in THF provided regioselectively 3

New ligands with affinity for the α4β2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling

A new series of piperazines, diazepanes, diazocanes, diazabicyclononanes, and diazabicyclodecanes with affinity for the α4β 2 subtype of nicotinic acetylcholine receptors were synthesized on the basis of results from a previous computational study. A predictive 3D-QSAR model was developed using the GRID/GOLPE approach (R2 = 0.94, Q 2 = 0.83, SDEP = 0.34). The SAR was interpreted in terms of contour maps of the PLS coefficients and in terms of a homology model of the α4β2 subtype of the nicotinic acetylcholine receptors. The results reveal that hydrogen bonding from both hydrogens on the protonated amine and from the pyridine nitrogen to a water molecule as well as van der Waals interactions between the substituent bearing the protonated amine and the receptor is of importance for ligand affinity. The combination of 3D-QSAR and homology modeling proved successful for the interpretation of structure-affinity relationships as well as the validation of the individual modeling approaches.

Novel heteroaryl-diazabicycloalkanes

The present invention relates to novel heteroaryl-diazabicycloalkanes which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment