22381-53-9

Basic information

• Product Name: 2-CHLOROETHYL P-TOLYL SULFONE
• Synonyms: BUTTPARK 147\15-27;2-CHLOROETHYL P-TOLYL SULFONE;2-CHLOROETHYL P-TOLYL SULPHONE;1-[(2-CHLOROETHYL)SULFONYL]-4-METHYLBENZENE;1-[(2-chloroethyl)sulphonyl]-4-methylbenzene;2-CHLOROETHYL (4-METHYLPHENYL)SULFONE;Benzene, 1-[(2-chloroethyl)sulfonyl]-4-methyl-;p-Toluene 2-chloroethyl sulphone
• CAS NO: 22381-53-9
• Molecular Formula: C₉H₁₁ClO₂S
• Molecular Weight: 218.7
• Mol File: 22381-53-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 77 °C
• Boiling Point: 367°Cat760mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 2.97E-05mmHg at 25°C
• Refractive Index: 1.531
• BRN: 1107627
• CAS DataBase Reference: 2-CHLOROETHYL P-TOLYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROETHYL P-TOLYL SULFONE(22381-53-9)
• EPA Substance Registry System: 2-CHLOROETHYL P-TOLYL SULFONE(22381-53-9)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 22381-53-9(Hazardous Substances Data)

Usage

General Description

2-Chloroethyl p-tolyl sulfone is a chemical compound with a molecular formula of C9H11ClO2S. It is a synthetic chemical compound used mainly in the production of other chemicals or as an intermediate in pharmaceutical manufacturing. Its systematic name is 1-(4-methylphenyl)sulfonyl-2-chloroethane. 2-CHLOROETHYL P-TOLYL SULFONE is generally characterized by sulfone, benzene and Chloroethyl groups in its structure. It requires careful handling due to potential human health risks associated with exposure. The precise nature of these risks, however, would depend on the specific circumstances surrounding its use or the individual's exposure to it.

InChI:InChI=1/C9H11ClO2S/c1-8-2-4-9(5-3-8)13(11,12)7-6-10/h2-5H,6-7H2,1H3

Upstream product

• 20761-71-1 (2-chloro-ethyl)-p-tolyl sulfide 
• 22381-54-0 2-(p-tolylsulfonyl)ethanol 
• 13290-16-9 2-(p-tolylthio)-ethanol 
• 106-45-6 para-thiocresol 
• 107-07-3 2-chloro-ethanol 
• 74-85-1 ethene 
• 98-59-9 p-toluenesulfonyl chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 107-04-0 1-Bromo-2-chloroethane 
• 22952-14-3 1,2-bis(p-tolylsulfonyl)ethane 

Downstream Products

• 5535-52-4 tolyl vinyl sulfone 
• 1457-31-4 7-(2-Chlor-ethyl)-7H-benzophenthiazin 
• 1457-32-5 7-(2-Chlor-aethyl)-7H-dibenzophenthiazin 
• 1457-36-9 14-(2-Chlor-aethyl)-14H-dibenzophenthiazin 
• 1975-02-6 12-(2-Chlor-ethyl)-12H-benzophenthiazin 
• 95017-64-4 N-(2-chloroethyl)-4-fluoro-N-(4-fluorophenyl)benzenamine 
• 17918-95-5 4-(2-Chloroethylsulfonyl)-benzoic acid 
• 2525-70-4 Thioessigsaeure-<2-(p-toluolsulfonyl-ethyl)-ester> 
• 15717-50-7 E-ditosylethene 
• 799260-84-7 (3-methyl-3-nitro-butyl)-p-tolyl sulfone 
• 773-59-1 cis-β-Bromovinyl p-tolyl sulfone 
• 878-80-8 trans-β-Bromovinyl p-tolyl sulfone 
• 65972-19-2 1-phenylsulfanyl-2-(toluene-4-sulfonyl)-ethane 
• 90919-62-3 <2-Chlor-ethyl>-<4-methoxycarbonyl-phenyl>-sulfon 

Relevant articles and documents

Synthesis of a new class of arylsulfonylethylsulfonylmethyloxazolines and thiazolines

A new class of arylsulfonylethylsulfonylmethyl oxazolines and thiazolines were prepared using multistep, one-pot methodologies exploiting lanthanide alkoxides and under microwave irradiation. The microwave method provides an excellent approach in a single step with high yields.

MODERN FRIEDEL-CRAFTS CHEMISTRY. XI. CYCLIZATION OF ARYL HALOALKYL SULFONES, ARYLSULFONYLACYL CHLORIDES AND THEIR CORRESPONDING SULFIDES

The sulfone group deactivation for cyclialkylation and cycliacylation reactions in the presence of Friedel-Crafts catalysts was demonstrated in a number of aryl chloroalkylsulfones (1-8) and arylsulfonylacyl chlorides (17a-22a), respectively.As expected, the corresponding arylchloroalkyl sulfides (9-16) and arylmercaptoacyl chlorides (13a-28a) underwent ring-closure reaction in most cases under the same conditions.The ease of cyclization was governed by the ring size, the stability of the attacking carbocation and the nucleophilicity of the aryl moiety.Also, the behaviour of benzyl sulfones (29, 31a, and 32a) and sulfides (33, 34a and 36a) was inconsistent.Noteworthy, the Friedel-Crafts cyclization reaction is thus considered an accessible method for the synthesis of compounds 37-41 and 45, 51.