224052-18-0

Basic information

• Product Name: 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-hydroxy-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester
• CAS NO: 224052-18-0
• Molecular Weight: 738.705
• Mol File: 224052-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-hydroxy-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-hydroxy-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester(224052-18-0)
• EPA Substance Registry System: 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-hydroxy-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester(224052-18-0)

Safety Data

• Hazardous Substances Data: 224052-18-0(Hazardous Substances Data)

Upstream product

• 90742-22-6 2'-O-(tetrahydropyran-2-yl)-N⁴-anysoylcytidine 
• 197238-39-4 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid 
• 189256-18-6 2-(4-Oxo-pentanoyloxymethyl)-benzoic acid 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 224052-21-5 5-Nitro-2-(4-oxo-pentanoyloxymethyl)-benzoic acid (2R,3R,4R,5R)-3-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl group as the novel base-labile protecting group for the 5'-hydroxyl groups of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites

A novel 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting group for the 5' position of nucleoside 3'-phosphoramidites was successfully applied to the solid-phase synthesis of both an oligodeoxyribonucleotide (TpTpT and TpTpTpT) and an octaribonucleotide in combination with a 2'-O-Thp protecting group (UpCpApGpUpUpGpG). The LMNBz group was simply unmasked due to its base-labile property by a two-step procedure, i.e., treatments with 0.5 M hydrazine hydrate in 1:4 acetic acid - pyridine, and then with 0.5 M imidazole in acetonitrile.