22410-58-8Relevant articles and documents
Alpha-halo-β-(substituted)thioacrylonitriles and their use for inhibiting the growth of microorganisms
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, (2008/06/13)
Userful as antimicrobial agents in aqeuous systems are α-haloβ-(substituted)thioacrylonitriles of the formula STR1 wherein X represents Cl, Br or I and R represents a lower alkyl, aryl, aralkyl, heterocyclo, or a thiocarbonyl group. The configuration about the double bond may be E or Z or a mixture thereof. These compounds provide effective control of microbial growth. The derivatives of formula I are economically prepared from acrylonitrile via a three-step process involving (a) halogenation, (b) dehydrohalogenation and (c) nucleophilic-type displacement. Except for those compounds wherein X is bromo and R is methyl or phenyl, the compounds of formula I are not mentioned in the prior art.