22422-22-6

Basic information

• Product Name: 3-chloro-1-(2,4-dimethylphenyl)propan-1-one
• Synonyms: 3-chloro-1-(2,4-dimethylphenyl)propan-1-one
• CAS NO: 22422-22-6
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 0
• Mol File: 22422-22-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 304.6°Cat760mmHg
• Flash Point: 162.3°C
• Appearance: /
• Density: 1.084g/cm³
• Vapor Pressure: 0.000868mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 3-chloro-1-(2,4-dimethylphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(2,4-dimethylphenyl)propan-1-one(22422-22-6)
• EPA Substance Registry System: 3-chloro-1-(2,4-dimethylphenyl)propan-1-one(22422-22-6)

Safety Data

• Hazardous Substances Data: 22422-22-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13ClO/c1-8-3-4-10(9(2)7-8)11(13)5-6-12/h3-4,7H,5-6H2,1-2H3

Upstream product

• 108-38-3 m-xylene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 34880-92-7 2,4-dimethyl-1-acryloylbenzene 
• 22430-64-4 4,6-dimethyl-1H-indene 
• 898764-27-7 1-(2,4-dimethylphenyl)-3-phenylpropan-1-one 
• 22422-28-2 (+/-)-3-Chlor-1-(2',4'-dimethyl-phenyl)-1-propanol 
• 21847-96-1 1-(2',4'-dimethylphenyl)-4-metylpentan-1-one 

Relevant articles and documents

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).

Synthesis of di- and tetraalkyl-3-piperazinoisoquinolines and related compounds as potential antidepressant agents

-