2243-53-0

Basic information

• Product Name: TRANS-STYRYLACETIC ACID
• Synonyms: STYRYLACETIC ACID;TRANS 4-PHENYL-3-BUTENOIC ACID;(3E)-4-Phenyl-3-butenoic acid;3-Butenoic acid, 4-phenyl-;4-phenylbut-3-enoic acid
• CAS NO: 2243-53-0
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• EINECS: 218-814-1
• Mol File: 2243-53-0.mol
• Article Data: 77

Chemical Properties

• Melting Point: 84-86 °C(lit.)
• Boiling Point: 302°C (estimate)
• Flash Point: 215.8°C
• Appearance: /
• Density: 1.0613 (rough estimate)
• Refractive Index: 1.5678 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: TRANS-STYRYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-STYRYLACETIC ACID(2243-53-0)
• EPA Substance Registry System: TRANS-STYRYLACETIC ACID(2243-53-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 2243-53-0(Hazardous Substances Data)

Usage

General Description

Trans-styrylacetic acid, also known as trans-4-phenylbut-3-enoic acid, is an organic compound with the chemical formula C10H10O2. It is a derivative of styrene and belongs to the aromatic carboxylic acid family. This chemical is a white solid with a melting point of around 105°C and is insoluble in water. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. Trans-styrylacetic acid has been studied for its potential anti-inflammatory, anti-tumor, and anti-oxidant properties, making it a promising candidate for future drug development and medical research.

InChI:InChI=1S/C10H10O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-7H,8H2,(H,11,12)/b7-4+

Upstream product

• 110-86-1 pyridine 
• 60341-39-1 (E)-4-phenylbut-2-enoic acid 
• 141-82-2 malonic acid 
• 122-78-1 phenylacetaldehyde 
• 108-30-5 succinic acid anhydride 
• 150-90-3 sodium succinate 
• 100-52-7 benzaldehyde 
• 300-57-2 allylbenzene 
• 109-72-8 n-butyllithium 
• 873-66-5 1-propenylbenzene 
• 1822-71-5 n-pentylsodium 
• 2243-52-9 3-benzylacrylic acid 
• 118171-45-2 1-[(1E)-4,4-dichloro-1,3-butadienyl]benzene 
• 861321-23-5 2-oxo-5-phenyl-tetrahydro-furan-3,4-dicarboxylic acid 

Downstream Products

• 76006-58-1 (E)-4-Phenyl-1-piperidino-3-buten-1-one 
• 37913-72-7 2-(4-Phenyl-1,3-butadienyl)thiophen 
• 24891-74-5 4-phenyl-but-3-enoic acid methyl ester 
• 4475-21-2 styryl-malonic acid 
• 5629-57-2 ethyl cinnamate 
• 2243-52-9 3-benzylacrylic acid 
• 6828-41-7 3-hydroxy-4-phenylbutanoic acid 
• 36598-07-9 4-iodo-5-phenyl-dihydro-furan-2-one 
• 90-15-3 α-naphthol 
• 583-06-2 3-benzoylacrylic acid 
• 19078-75-2 4-bromo-4-phenyl-butyric acid 
• 90921-36-1 4-phenyl-but-3-enoic acid amide 
• 59710-69-9 tert-butyl 4-phenylperbutenoate 
• 60773-92-4 β-benzalpropionic acid chloride 

Relevant articles and documents

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Photo-Promoted Decarboxylative Alkylation of α, β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β, γ-Unsaturated Nitriles

An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis.

Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive.