224449-33-6

Basic information

• Product Name: 4-Bromo-3-thiophenecarboxylic acid ethyl ester
• Synonyms: 4-Bromo-3-thiophenecarboxylic acid ethyl ester;ethyl 4-bromothiophene-3-carboxylate
• CAS NO: 224449-33-6
• Molecular Formula: C₇H₇BrO₂S
• Molecular Weight: 235.09828
• Mol File: 224449-33-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 260.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.572±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Bromo-3-thiophenecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-thiophenecarboxylic acid ethyl ester(224449-33-6)
• EPA Substance Registry System: 4-Bromo-3-thiophenecarboxylic acid ethyl ester(224449-33-6)

Safety Data

• Hazardous Substances Data: 224449-33-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-thiophenecarboxylic acid ethyl ester is a chemical compound that is derived from thiophene, a five-membered heterocyclic compound containing sulfur. It is used primarily as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-Bromo-3-thiophenecarboxylic acid ethyl ester is often employed in organic synthesis and medicinal chemistry as a building block for more complex molecules. It is a valuable reagent due to its ability to undergo various reactions, such as esterification and bromination, making it a versatile starting material for the production of a wide range of compounds. Its ethyl ester form also provides unique properties that may be beneficial in certain chemical reactions and applications. Overall, 4-Bromo-3-thiophenecarboxylic acid ethyl ester is an important chemical compound with various industrial and research applications.

Upstream product

• 3141-26-2 3,4-dibromothiophene 
• 541-41-3 chloroformic acid ethyl ester 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 
• 57279-53-5 6-phenyl-5H-thieno[3,4-c]pyridin-4-one 
• 70438-00-5 4-ethoxy-thiophene-3-carboxylic acid 
• 57279-64-8 4-(2-oxo-2-phenylethyl)thiophene-3-carboxylic acid 
• 686271-29-4 (4-benzylsulfanyl-5-nitro-thiophen-3-yl)-methanol 
• 1002761-78-5 4-benzylsulfanyl-5-nitro-thiophene-3-carboxylic acid ethyl ester 
• 1002761-79-6 3-benzylsulfanyl-4-chloromethyl-2-nitro-thiophene 
• 1002761-80-9 N-tert-butyl ester-N-(4-benzylsulfanyl-5-nitro-thiophen-3-ylmethyl)-methanesulfonamide 

Relevant articles and documents

Synthesis of Tetrasubstituted Thiophenes via Direct Metalation

Thiophene moiety can be derivatized by various synthetic procedures. The most convenient method seems to be derivatization via direct metalation, but synthesis of polysubstituted thiophenes bearing reactive groups is difficult because of high reactivity of organometallic reagents. This work reports the preparation of complex heterocyclic compounds using direct metalation of thiophenes with various reagents (Knochel-Hauser bases, LDA) as an efficient synthetic tool.

PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

PIPERIDINE OXADIAZOLE AND THIADIAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to piperidine oxadiazole and thiadiazole orexin compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the prevention or treatment of such diseases in which orexin receptors are involved.