22446-12-4 Usage
Description
4-METHOXYPHENOXYACETONITRILE is an organic compound that serves as an important intermediate in the synthesis of various organic compounds, particularly in the production of α-aryloxy-2,4-dihydroxyacetophenone 4-O-β-D-glucopyranosides and their conversion into 3-aryloxy-7-glucosyloxychromones.
Uses
Used in Pharmaceutical Industry:
4-METHOXYPHENOXYACETONITRILE is used as a key intermediate in the synthesis of α-aryloxy-2,4-dihydroxyacetophenone 4-O-β-D-glucopyranosides, which are valuable compounds in the development of pharmaceuticals. These compounds exhibit various biological activities, making them essential in the creation of new drugs and therapeutic agents.
Used in Organic Synthesis:
4-METHOXYPHENOXYACETONITRILE is used as a versatile building block in organic synthesis for the production of various organic compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in the Production of 3-aryloxy-7-glucosyloxychromones:
4-METHOXYPHENOXYACETONITRILE is used as a precursor in the conversion process to produce 3-aryloxy-7-glucosyloxychromones. These chromones are important compounds with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 22446-12-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,4 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22446-12:
(7*2)+(6*2)+(5*4)+(4*4)+(3*6)+(2*1)+(1*2)=84
84 % 10 = 4
So 22446-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO2/c1-11-8-2-4-9(5-3-8)12-7-6-10/h2-5H,7H2,1H3
22446-12-4Relevant articles and documents
Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile
Li, Yingmin,Guo, Mengping,Wen, Yongju,Zhou, Lanjiang,Shen, Xiuli,Kang, Yangping
supporting information, (2020/09/09)
A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.
SELECTIVE GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 34; 52, (2015/06/03)
Described herein are certain steroid derivative compounds, for example of formula (I): wherein X1, X2, X3 L, and Ar are as defined herein, pharmaceutical compositions comprising such compounds, the use of such compounds and compositions to specifically target glucocorticoid action, and the use of such compounds and compositions in the treatment of acute and chronic inflammatory conditions, in particular rheumatoid arthritis, haematological and other malignancies, and for causing immunosuppression in the prevention or treatment of transplant rejection, as well as methods of preparing such compounds.
CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER
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Page/Page column 15, (2010/12/18)
4-Chromenone derivatives of the formula I herein that inhibit the ubiquitin-mediated degradation of p27, are useful for the treatment of cancer.
Xn:Harmful;
