2245-53-6Relevant articles and documents
Application of novel copper organic material for facile microextraction of sodium valproate from human plasma samples: Experimental design optimization and isotherm study
Bahrani, Sonia,Ghaedi, Mehrorang,Taghipour, Tahere,Mansoorkhani, Mohammad Javad Khoshnood,Bagheri, Ahmad Reza,Ostovan, Abbas
, (2018)
Well-designed metal organic materials (MOMs) were synthesized and applied for pre-concentration and determination of sodium valproate (Na-VP) from biological samples, bound to the copper complex of 1,4-phenylenedioxydiacetic acid under mild conditions. The channels of this sorbent provide high efficiency and also selectivity. The MOMs were structurally characterized using Fourier transform infrared and energy-dispersive X-ray spectroscopies, scanning electron microscopy and X-ray diffraction, and they were found to have suitable features for quantification of Na-VP using HPLC coupled with UV detection at λ?=?215?nm. Moreover, the rate of adsorption is improved by ultrasonic power and the experimental data are best fitted according to Freundlich adsorption isotherm. According to the central composite design, the best experimental conditions are 280.0?μl, 3.0?min and 17.0?mg for volume of eluent, sonication time and sorbent mass respectively. Calibration plots show linear responses towards Na-VP concentrations (0.4–18.0?μg ml?1), satisfactory limit of detection (0.06?μg ml?1, S/N?=?3) and reasonable enrichment factor (70.58). The coefficient of variation values of both inter- and intra-day analyses were less than 4.0%, indicating a candidate method for the determination of Na-VP in human plasma with reasonable recovery and efficiency.
Photoelectro-Fenton/photocatalytic process for decolorization of an organic compound by Ag:Cd-1,4-BDOAH2 nano-photocatalyst: Response surface modeling and central composite design optimization
Taghipour, Tahere,Karimipour, Gholamreza,Ghaedi, Mehrorang,Asfaram, Arash,Javadian, Hamedreza,Sabzehmeidani, Mohammad Mehdi,Karimi, Hajir
, (2021/04/19)
In the present research, the synthesis of the cadmium-benzene-1,4-dioxyacetic acid (Cd-1,4-BDOAH2) was carried out by the assistance of ultrasound waves, and then it was loaded with the low amount of Ag nano-particles. Subsequently, the Ag:Cd-1,4-BDOAH2 nano-photocatalyst was applied for photoelectro-Fenton/photocatalytic (PEF-PH) degradation of brilliant green (BG) in the existence of visible light in aqueous media. The synthesized composite was characterized by FTIR, SEM, EDX, TEM, XRD, DRS, and PL. The best operational conditions including time, initial BG concentration, pH, amount of photocatalyst, current and amount of FeCl3 on degradation efficiency (main and interactive) were as follows: 4 mg L?1 of BG at pH of 5, 0.4 g L?1 of Ag:Cd-1,4-BDOAH2, 250 mA of current, and 0.3 mmol L?1 of FeCl3 obtained by central composite design. The PEF-PH degradation kinetic data of BG were successfully fitted to Langmuir–Hinshelwood (L–H) model with the values of 1.16 mg L?1 min?1 and 0.018 L mg?1 for the rate constant (kr) and (KA), respectively.
Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols
Pawe?czyk, Anna,Sowa-Kasprzak, Katarzyna,Olender, Dorota,Zaprutko, Lucjusz
, (2018/09/26)
Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.
