22467-31-8 Usage
Description
Rubratoxin A, a natural mycotoxin, is a potent and selective competitive inhibitor of protein phosphatase 2A (PP2A) with an IC50 value of 170 nM. It specifically targets PP2A without significantly affecting other phosphatases such as PP1, PP2B, and protein tyrosine phosphatase 1B. This unique specificity allows Rubratoxin A to drive overphosphorylation of PP2A substrate proteins in cultured cells, leading to various biological effects.
Uses
Used in Pharmaceutical Industry:
Rubratoxin A is used as a research tool for studying the role of PP2A in cellular processes. Its high specificity and potency make it a valuable compound for investigating the functions and regulation of PP2A in various cellular pathways.
Used in Cancer Research:
Rubratoxin A is used as a potential therapeutic agent in cancer research. It has been shown to suppress tumor metastasis and reduce the volume of primary tumors in mouse xenografts. This suggests that Rubratoxin A could be a promising candidate for the development of novel cancer treatments, particularly for targeting PP2A-related pathways in cancer cells.
Used in Drug Development:
Rubratoxin A can be used in the development of new drugs targeting PP2A. Its ability to selectively inhibit PP2A makes it a valuable starting point for designing new compounds with improved pharmacological properties, such as better bioavailability, reduced toxicity, and enhanced efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 22467-31-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,6 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 22467-31:
(7*2)+(6*2)+(5*4)+(4*6)+(3*7)+(2*3)+(1*1)=98
98 % 10 = 8
So 22467-31-8 is a valid CAS Registry Number.
