22503-72-6 Usage
Description
IDRA 21, also known as benzothiadiazine derivative, is a positive allosteric modulator of glutamate AMPA receptors. It is a white to off-white crystalline powder that has the ability to inhibit AMPA receptor desensitization, thereby enhancing cognition. IDRA 21 is more capable of crossing the blood-brain barrier than Cyclothiazide (C988960), making it a promising candidate for various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
IDRA 21 is used as a cognitive enhancer for patients with cognitive impairments such as Alzheimer's disease. It works by inhibiting AMPA receptor desensitization, which in turn increases excitatory synaptic strength and may help ameliorate memory deficits.
Additionally, IDRA 21 is used as a research tool to study the role of AMPA receptors in cognitive functions and the potential therapeutic effects of modulating these receptors in various neurological disorders.
Used in Research and Development:
IDRA 21 serves as a valuable compound in the development of new drugs targeting AMPA receptors. Its ability to cross the blood-brain barrier and enhance cognition makes it an important molecule for exploring novel therapeutic strategies for cognitive impairments and other related conditions.
Biological Activity
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).
Check Digit Verification of cas no
The CAS Registry Mumber 22503-72-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,5,0 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22503-72:
(7*2)+(6*2)+(5*5)+(4*0)+(3*3)+(2*7)+(1*2)=76
76 % 10 = 6
So 22503-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
22503-72-6Relevant articles and documents
Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues
Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi
, p. 2099 - 2102 (2018/05/04)
A general metal-free oxidative cyclization process has been developed for the synthesis of quinazolinones, benzothiadiazines and quinazolines. By this protocol, a range of substituted 2-aminobenzamides, 2-aminobenzenesulfonamide and 2-(aminomethyl)anilines react with various alcohols, leading to the desired annulated products smoothly. This protocol features many advantages as broad substrate scope, mild reaction conditions, low environmental pollution, high atom-economy and good to excellent yields.
ANTIHYPERTENSIVE AGENTS. I. NON-DIURETIC 2H-1,2,4-BENZOTHIADIAZINE
TOPLISS,SHERLOCK,REIMANN,KONZELMAN,SHAPIRO,PETTERSEN,SCHNEIDER,SPERBER
, p. 122 - 127 (2007/10/05)
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