225108-20-3

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonothioate), compd. with N,N-diethylethanamine (1:1)
• CAS NO: 225108-20-3
• Molecular Formula: C31H33N2O8PS.C6H15N
• Molecular Weight: 725.843
• Mol File: 225108-20-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonothioate), compd. with N,N-diethylethanamine (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonothioate), compd. with N,N-diethylethanamine (1:1)(225108-20-3)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(hydrogen phosphonothioate), compd. with N,N-diethylethanamine (1:1)(225108-20-3)

Safety Data

• Hazardous Substances Data: 225108-20-3(Hazardous Substances Data)

Upstream product

• 117872-98-7 triethylammonium hypophosphite 
• 40615-39-2 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-hydroxy-5-methyl-1H-pyrimidin-2-one 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 121-44-8 triethylamine 
• 4712-55-4 diphenyl hydrogen phosphite 

Downstream Products

• 173204-31-4 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate 
• 650601-57-3 O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(2',3'-dideoxythymidin-5'-yl) H-thiophosphonate 
• 1035457-84-1 C₆H₁₅N*C₃₂H₃₅N₂O₉PS 
• 1035457-89-6 C₆H₁₅N*C₃₅H₄₁N₂O₉PS 
• 124667-73-8 C₅₃H₅₇N₄O₁₄PS 
• 182245-84-7 C₃₆H₃₆N₃O₈PS 
• 650601-44-8 O-(5'-dimethoxytrityl-2'-deoxythymidin-3'-yl)-O-(3'-azido-2'-deoxythymidin-5'-yl) H-thiophosphonate 
• 351341-22-5 5'-O-(dimethoxytrityl)thymidin-3'-yl 3'-O-(dimethoxytrityl)thymidin-5'-yl H-phosphonothioate 
• 351341-22-5 5'-O-(dimethoxytrityl)thymidin-3'-yl 3'-O-(dimethoxytrityl)thymidin-5'-yl H-phosphonothioate 
• 157793-51-6 3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate 
• 135257-77-1 C₄₈H₄₉N₄O₁₃PS 

Relevant articles and documents

Silylation-mediated transesterification of O-phenyl H-phosphonothioates - A new entry to nucleoside H-phosphonothioate monoesters

O-Phenyl H-phosphonothioate undergoes a facile transesterification with suitably protected nucleosides upon in situ silylation with tert- butyldiphenylsilyl chloride in pyridine/toluene to produce the corresponding 3′-H-phosphonothioates in good yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Aryl H-Phosphonates. 12. Synthetic and 31P NMR Studies on the Preparation of Nucleoside H-Phosphonothioate and Nucleoside H-Phosphonodithioate Monoesters

Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using 31P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.

NUCLEOSIDE H-PHOSPHONATES. X. STUDIES ON NUCLEOSIDE HYDROGENPHOSPHONOTHIOATE DIESTER SYNTHESIS

Synthesis and chemical properties of nucleoside H-phosphonothioates are discussed in the context of possible application of these compounds as intermediates in the synthesis of oligonucleotide analogues.