225122-54-3

Basic information

• Product Name: 3-chloromethyl-benzoic acid allyl ester
• Synonyms: 3-chloromethyl-benzoic acid allyl ester
• CAS NO: 225122-54-3
• Molecular Weight: 210.66
• Mol File: 225122-54-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-chloromethyl-benzoic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloromethyl-benzoic acid allyl ester(225122-54-3)
• EPA Substance Registry System: 3-chloromethyl-benzoic acid allyl ester(225122-54-3)

Safety Data

• Hazardous Substances Data: 225122-54-3(Hazardous Substances Data)

Upstream product

• 106-95-6 allyl bromide 
• 31719-77-4 3-chloromethylbenzoic acid 
• 107-18-6 allyl alcohol 

Downstream Products

• 1068437-11-5 prop-2-enyl 3-{[3-(4-hydroxyphenyl)-4-oxo-3-hydroquinazolin-7-yloxy]methyl} benzoate 
• 225122-55-4 allyl 3-(iodomethyl)benzoate 
• 515846-46-5 (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid allyl ester 
• 515846-48-7 (R)-3-[4-(5-{1-[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-2,3-dichloro-phenoxymethyl]benzoic acid 

Relevant articles and documents

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Rα) with cell-based activity. Starting with a low micromolar hit, we employed a combination