2253-33-0

Basic information

• Product Name: ethyl 2-fluoro-3-oxopropanoate
• Synonyms: ethyl 2-fluoro-3-oxopropanoate
• CAS NO: 2253-33-0
• Molecular Formula: C5H7FO3
• Molecular Weight: 134.1056832
• Mol File: 2253-33-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 137.7±30.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• PKA: 5.42±0.29(Predicted)
• CAS DataBase Reference: ethyl 2-fluoro-3-oxopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-fluoro-3-oxopropanoate(2253-33-0)
• EPA Substance Registry System: ethyl 2-fluoro-3-oxopropanoate(2253-33-0)

Safety Data

• Hazardous Substances Data: 2253-33-0(Hazardous Substances Data)

Upstream product

• 459-72-3 ethyl 2-fluoroacetate 
• 109-94-4 formic acid ethyl ester 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 125950-56-3 Fluoroocarboethoxymethylene tri-n-butylphosphorane 

Downstream Products

• 1993-92-6 2-fluoro-3-hydroxypropionic acid ethyl ester 

Relevant articles and documents

Preparation of α-fluoro-β-per(poly) fluoroalkyl-substituted enol ethers

Fluorocarboethoxymethylene tri-n-butylphosphorane, Bu3P=CFCOOEt (3), reacts with per- and poly-fluoroalkyl-substituted carboxylic acid esters, ethyl formate and γ-butyrolactone to give the corresponding enol ethers, RFC (OEt)=CFCOOEt (4), in good yield. Non-activated esters failed to react with 3. With the anion derived from ethyl diethylphosphonofluoroacetate, (EtO)2P(O)CFHCOOEt (5), a mixture of 4 and β-ketoesters, RFC(O)CFHCOOEt (7), is formed.