225385-03-5

Basic information

• Product Name: Thieno[3,2-d]pyrimidine,6-bromo-4-chloro-
• Synonyms: 6-Bromo-4-chlorothieno[3,2-d]pyrimidine
• CAS NO: 225385-03-5
• Molecular Formula: C₆H₂BrClN₂S
• Molecular Weight: 249.5155
• EINECS: 635-520-2
• Product Categories: CHIRAL CHEMICALS;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 225385-03-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 345.5oC at 760 mmHg
• Flash Point: 162.7oC
• Appearance: /
• Density: 1.955
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.735
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.19±0.40(Predicted)
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine,6-bromo-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine,6-bromo-4-chloro-(225385-03-5)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine,6-bromo-4-chloro-(225385-03-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 225385-03-5(Hazardous Substances Data)

Usage

General Description

Thieno[3,2-d]pyrimidine,6-bromo-4-chloro- is a chemical compound with a complex molecular structure consisting of a thieno[3,2-d]pyrimidine core, with bromine and chlorine atoms attached at the 6th and 4th positions, respectively. Thieno[3,2-d]pyrimidine,6-bromo-4-chloro- has potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. It may be used as a building block in the synthesis of novel pharmaceutical compounds or as a research tool in chemical biology. The precise properties and uses of this chemical may vary depending on the specific context and intended application, and further research and experimentation may be necessary to fully understand its potential.

InChI:InChI=1/C6H2BrClN2S/c7-4-1-3-5(11-4)6(8)10-2-9-3/h1-2H

Upstream product

• 16269-66-2 4-chlorothieno[3,2-d]pyrimidine 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 16234-10-9 3H-thieno[3,2-d]pyrimidin-4-one 
• 16285-69-1 3-(formylamino)-2-thiophenecarboxylic acid methyl ester 
• 124-73-2 1,2-dibromo-1,1,2,2-tetrafluoroethane 
• 4111-54-0 lithium diisopropyl amide 

Downstream Products

• 875798-27-9 N-{4-[2-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-ethyl]-phenyl}-3-trifluoromethyl-benzamide 
• 552295-33-7 6-bromo-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)thieno[3,2-d]pyrimidin-4-amine 
• 1228102-67-7 6-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine 
• 1228101-03-8 (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(3-methoxy-phenyl)-amine 
• 1228102-80-4 6-(5-(1,3-dioxolane-2-yl)thiophen-2-yl)-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-d]pyrimidin-4-amine 
• 1228102-81-5 5-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)thiophene-2-carboxaldehyde 
• 1228101-07-2 3-(6-bromo-thieno[3,2-d]pyrimidin-4-ylamino)-phenol 
• 1228101-09-4 3-[6-(4-methoxyphenyl)-thieno[3,2-d]pyrimidin-4-ylamino]-phenol 
• 1228101-19-6 (3-methoxyphenyl)-(6-thiophen-2-yl-thieno[3,2-d]pyrimidin-4-yl)-amine 
• 1228102-08-6 3-(6-thiophen-2-yl-thieno[3,2-d]pyrimidin-4-ylamino)-phenol 
• 1228103-15-8 N-(3-(4-methoxybenzyloxy)phenyl)-6-(5-(pyrrolidin-1-ylmethyl)thiophen-2-yl)thieno[3,2-d]pyrimidin-4-amine 
• 1228102-79-1 3-(4-(3-(4-methoxybenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)benzaldehyde 
• 1228102-70-2 6-bromo-N-(3-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria

Target repurposing is a proven method for finding new lead compounds that target Trypanosoma brucei, the causative agent of human African trypanosomiasis. Due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against T. brucei (EC50 = 42 nM) and selectivity over human host cells, we have explored other classes of human tyrosine kinase inhibitor scaffolds in order to expand the range of chemotypes for pursuit. Following library expansion, we found compound 11e to have an EC50 of 84 nM against T. brucei cells while maintaining selectivity over human hepatocytes. In addition, the library was tested against causative agents of Chagas' disease, leishmaniasis, and malaria. Two analogs with sub-micromolar potencies for T. cruzi (4j) and Plasmodium falciparum (11j) were discovered, along with an analog with considerable potency against Leishmania major amastigotes (4e). Besides identifying new and potent protozoan growth inhibitors, these data highlight the value of concurrent screening of a chemical library against different protozoan parasites. This journal is

ANTI-INFLAMMATORY COMPOUND HAVING INHIBITORY ACTIVITY AGAINST MULTIPLE TYROSINE KINASES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

INDOLYLALKYLTHIENOPYRIMIDYLAMINES AS MODULATORS OF THE EP2 RECEPTOR

The present invention relates to indolylalkylthienopyhmidylamines of the general formula (I), to processes for their preparation and to their use for production of pharmaceutical compositions for treatment of disorders and indications connected to the EP2