225518-71-8Relevant articles and documents
Synthesis of cyclopropane substrate analog for 3-isopropylmalate dehydrogenase and its mechanism-based inhibition
Chiba, Akira,Eguchi, Tadashi,Oshima, Tairo,Kakinuma, Katsumi
, p. 2927 - 2936 (1999)
A cyclopropane substrate analog 1 was designed as a mechanism-based inhibitor for 3-isopropylmalate dehydrogenase (IPMDH), the rate-determining enzyme responsible for the penultimate step in the biosynthetic pathway of the essential amino acid L-leucine.