2256-86-2

Basic information

• Product Name: 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE
• Synonyms: 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE;TIMTEC-BB SBB010082;3-METHYLBENZOFURAN-2-CARBONYLCHLORIDE,97%;2-benzofurancarbonyl chloride, 3-methyl-;3-Methylbenzofuran-2-carbonyl chloride 97%;3-methyl-2-benzofurancarbonyl chloride
• CAS NO: 2256-86-2
• Molecular Formula: C₁₀H₇ClO₂
• Molecular Weight: 194.61
• Product Categories: Benzofurans;Building Blocks;Heterocyclic Building Blocks
• Mol File: 2256-86-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 72-77 °C(lit.)
• Boiling Point: 285.1°Cat760mmHg
• Flash Point: 126.2°C
• Appearance: /
• Density: 1.305g/cm³
• Vapor Pressure: 0.00287mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE(2256-86-2)
• EPA Substance Registry System: 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE(2256-86-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2256-86-2(Hazardous Substances Data)

Usage

Description

3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE is an organic compound that exists as a white to light yellow crystalline powder. It is characterized by its chemical structure, which includes a benzofuran ring with a methyl group at the third position and a carbonyl chloride group attached to the second position.

Uses

Used in Pharmaceutical Industry:
3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE is used as an intermediate compound for the synthesis of various pharmaceuticals. Its application is primarily due to its ability to react with other molecules to form new compounds with potential therapeutic properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE serves as a key building block for creating a range of organic compounds. Its reactivity and structural features make it a valuable component in the development of new molecules with specific applications.
Used in Synthesis of Ferruginyl 3-Methylbenzofuran-2-Carbonyl Ester:
3-METHYLBENZOFURAN-2-CARBONYL CHLORIDE is specifically used as a starting material for the synthesis of ferruginyl 3-methylbenzofuran-2-carbonyl ester. This ester derivative may have potential applications in various fields, such as pharmaceuticals or materials science, due to its unique chemical properties.

InChI:InChI=1/C10H7ClO2/c1-6-7-4-2-3-5-8(7)13-9(6)10(11)12/h2-5H,1H3

Upstream product

• 24673-56-1 3-methyl-1-benzofuran-2-carboxylic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 2076-36-0 methyl 3-methylbenzofuran-2-carboxylate 
• 34319-21-6 2-(3-methylbenzofuran-2-ylcarboxamido)benzoic acid 
• 1259398-79-2 C₂₆H₂₃N₃O₄S 
• 1333167-35-3 5-(4-phenoxyphenyl)-5-(4-(3-methylbenzofuran-2-carbonyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1350722-74-5 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[(3-methylbenzofuran-2-carbonyl)amino]isoxazole-3-carboxylic acid ethylamide 
• 92367-50-5 N-methyl-1-(3-methylbenzofuran-2-yl)methanamine 
• 952737-79-0 2-(3-methylbenzofuran-2-yl)quinazolin-4(3H)-one 
• 1047981-43-0 (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide benzenesulfonate 
• 1047981-31-6 (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide p-toluenesulfonate 

Relevant articles and documents

Pd(II)-Catalyzed Arylation and Intramolecular Amidation of γ-C(sp3)-H Bonds: En Route to Arylheteroarylmethane and Pyrrolidone Ring Annulated Furan/Thiophene Scaffolds

We report the Pd(II)-catalyzed, bidentate directing group (BDG)-assisted arylation and successive arylation/intramolecular amidation of γ-C(sp3)-H bonds. The Pd(II)-catalyzed BDG-assisted C-H activation and functionalization of the β-C(sp3)-H bonds of carboxylic acids are well documented, but only a few reports are available that deal with the BDG-directed functionalization of the γ-C(sp3)-H bonds. Various 3-methylthiophene/furan-2-carboxamides (1a-e) were derived from their corresponding carboxylic acids and bidentate directing groups. These compounds were then used as substrates to investigate the arylation and successive arylation/intramolecular amidation of the γ-C(sp3)-H bonds. The γ-C(sp3)-H arylation arose from the Pd(II)-catalyzed reactions of these compounds with aryl iodides with reaction periods of 4-24 h (except a few reactions which required 36 or 48 h). Notably, these reactions led to the construction of various unsymmetrical diarylmethane scaffolds, such as thiophene/furan-based arylheteroarylmethanes (3-6). Prolonging the reaction period to 48-70 h led to successive γ-C(sp3)-H arylation/intramolecular amidation and the construction of both C-C and C-N bonds. Accordingly, these reactions led to the construction of new classes of pyrrolidone-ring annulated thiophene/furan-based heterocyclic scaffolds (e.g., 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-ones (8), 4,5-dihydro-6H-furo[2,3-c]pyrrol-6-ones (10), and 1-phenyl-1,2-dihydro-3H-benzo[4,5]thieno[2,3-c]pyrrol-3-ones (12)), and notably, compounds 8, 10, and 12 resemble the skeletons of 3-phenylisoindolin-1-ones.

Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.