22560-50-5 Usage
Description
Dichloromethylenediphosphonic acid disodium salt, also known as Clodronate disodium, is a bisphosphonate compound with the chemical formula C2H4Cl2Na2O4P2. It is a white solid that serves as a bone resorption inhibitor and is used in various medical applications.
Uses
Used in Pharmaceutical Industry:
Dichloromethylenediphosphonic acid disodium salt is used as a bisphosphonate antiresorptive agent for inhibiting bone resorption. It is particularly effective in the treatment of osteolytic bone metastases and malignant hypercalcemia, where it helps manage severe hypercalcemia associated with malignancy and alleviates bone pain associated with skeletal metastases.
Used in Orthopedics:
In the field of orthopedics, Dichloromethylenediphosphonic acid disodium salt is utilized as a bone resorption inhibitor to prevent the loss of bone density and strength, which is crucial for maintaining the structural integrity of the skeletal system.
Brand Name:
The brand name for Dichloromethylenediphosphonic acid disodium salt is Bonefos, which is manufactured by Leiras Oy, Finland.
Originator
Proctor & Gamble (USA)
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Clinical Use
Bisphosphonate:
Management of osteolytic lesions, hypercalcaemia and
bone pain associated with skeletal metastases in patients
with breast cancer or multiple myeloma
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.
Metabolism
Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged
in the urine within 24 hours, the remainder being
sequestered to bone tissue. The substance which is bound
to bone is excreted more slowly, and the renal clearance is
about 75% of the plasma clearance.
Check Digit Verification of cas no
The CAS Registry Mumber 22560-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,5,6 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22560-50:
(7*2)+(6*2)+(5*5)+(4*6)+(3*0)+(2*5)+(1*0)=85
85 % 10 = 5
So 22560-50-5 is a valid CAS Registry Number.
InChI:InChI=1/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2