22565-10-2Relevant articles and documents
Hypervalent Iodine as a Terminal Oxidant in Wacker-Type Oxidation of Terminal Olefins to Methyl Ketones
Chaudhari, Dipali A.,Fernandes, Rodney A.
, p. 2113 - 2121 (2016/03/15)
A mimic of the Wacker process for C=O bond formation in terminal olefins can be initiated by a combination of the Pd(II) and hypervalent iodine reagent, Dess-Martin periodinane to generate methyl ketones. This operationally simple and scalable method offers Markovnikov selectivity, has good functional group compatibility, and is mild and high yielding.
Iron(III) sulfate as terminal oxidant in the synthesis of methyl ketones via wacker oxidation
Fernandes, Rodney A.,Chaudhari, Dipali A.
, p. 5787 - 5793 (2014/07/08)
An efficient and environmentally benign method using Fe(III) sulfate as a terminal oxidant in the synthesis of methyl ketones from terminal olefins via the Wacker process is developed. The methodology offers high selectivity for a Markonikov product, shows good functional group compatibility, involves mild reaction conditions, and is operationally simple. Fe2(SO 4)3 is the sole terminal oxidant in this process. The method holds potential for future applications in organic synthesis.