22568-07-6

Basic information

• Product Name: Benzene, 1-chloro-2-(2-nitroethenyl)-, (E)-
• Synonyms: 2-chloronitrostyrene
• CAS NO: 22568-07-6
• Molecular Formula: C8H6ClNO2
• Molecular Weight: 183.594
• Mol File: 22568-07-6.mol
• Article Data: 77

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-2-(2-nitroethenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-2-(2-nitroethenyl)-, (E)-(22568-07-6)
• EPA Substance Registry System: Benzene, 1-chloro-2-(2-nitroethenyl)-, (E)-(22568-07-6)

Safety Data

• Hazardous Substances Data: 22568-07-6(Hazardous Substances Data)

Usage

General Description

Benzene, 1-chloro-2-(2-nitroethenyl)-, (E)- is a chemical compound that is also known by the chemical name 2-chloro-1-(2-nitroethenyl)benzene. It is a colorless to light yellow liquid that is used primarily as an intermediate in the production of pesticides. The E isomer of this compound is the more stable and predominant form. It is considered to be a harmful chemical, with potential health effects including irritation of the eyes, skin, and respiratory tract, as well as potential carcinogenic properties. Due to its hazardous nature, it is important to handle and use this compound with proper safety precautions.

Upstream product

• 75-52-5 nitromethane 
• 89-98-5 2-chloro-benzaldehyde 
• 3752-25-8 o-chlorocinnamic acid 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 625-75-2 nitroacetic acid 
• 704-96-1 trans-2-chlorocinnamic acid 
• 2039-87-4 2-chlorostyrene 
• 79-24-3 Nitroethane 
• 108-90-7 chlorobenzene 
• 85536-83-0 1-(2-chloro-phenyl)-2-nitro-ethanol 
• 1794-45-2 2-chlorocinnamaldehyde 

Downstream Products

• 15851-93-1 2-chloro-5,β-dinitro-styrene 
• 147089-80-3 (Z)-1-(2-bromo-2-nitrovinyl)-2-chlorobenzene 
• 10125-44-7 2-Chlor-1-<1,3,3,3-tetranitro-propyl-2>-benzol 
• 10125-43-6 2-Chlor-1-<1,3,3-trinitro-butyl-2>-benzol 
• 10169-21-8 2-Chlor-1-(1,3,3-trinitropentyl-2)-benzol 
• 71872-90-7 2-<2-Chlor-α-nitromethyl-benzylmercapto>-ethylamin 
• 50368-41-7 5-(2-chloro-phenyl)-3-methyl-2-thioxo-[1,3,4]thiadiazinan-6-one oxime 
• 114809-73-3 [(2-Chloro-phenyl)-cyano-methyl]-phosphonic acid diethyl ester 
• 77484-21-0 dichloro-3,4 indolinone-2 
• 77484-31-2 acide N-acetyl chloro-2 (o.chlorophenyl)-2 acetohydroxamique 
• 77484-41-4 chlorure de l'acide N-acetoxy chloro-2 (o.chlorophenyl)-2 acetohydroximique 
• 90799-10-3 (1-<2-Chlor-phenyl>-2-nitro-ethylmercapto)-essigsaeure 
• 91089-81-5 3-(1-<2-Chlorphenyl>-2-nitro-ethylmercapto)-propionsaeure 
• 98018-72-5 6-Nitro-5-<2-chlorphenyl>-bicyclo<2.2.1>hepten-(2) 

Relevant articles and documents

Metal-free Synthesis of β-Nitrostyrenes via DDQ-Catalyzed Nitration

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Catalytic Asymmetric Construction of Tertiary Carbon Centers Featuring an α-Difluoromethyl Group with CF2H-CH2-NH2as the "building Block"

We report here for the first time a novel difluoromethylated ketimine building block condensed by thioisatin and difluoroethylamine, offering efficient access to a broad range of enantioenriched products bearing difluoroethylamine units (27 examples, ≤98% yield, >99% ee) in the presence of quinine-derived squaramide. Further transformation of the intermediate would generate a variety of versatile functional blocks like α-difluoromethyl amines, β-amino acid, and β-diamine with retention of the enantiomeric excess at the difluoromethyl-bound carbon.

Chiral 4 and 5 - disubstituted pyrrolidine -2 - ketone compound as well as preparation method and application thereof

The invention belongs to the technical field of organic synthesis, and particularly relates to chiral 4, 5 - disubstituted pyrrolidine -2 - ketone compounds as well as a preparation method and application thereof. The invention firstly uses nitro substituted alkyl (I) and trans α, β - unsaturated 3 - methyl -4 - nitroisoxazole (II) as raw materials, and the asymmetric Michael addition reaction of chiral superbase catalysis I and II is a key step and is hydrolyzed. Esterification and reduction closes the ring, synthesizing a chiral 3, 4 - disubstituted pyrrolidine -2 - ketone compound, including optically pure fenoxone. The asymmetric Michael addition reaction of chiral superbase catalyst for catalyzing 2 -substituted nitroethane (I) and trans α, β -unsaturated 3 - methyl -4 - nitroisoxazole (II) is used for preparing chiral 4 and 5 -disubstituted pyrroli -2 - ketone, and a strapdown is provided for synthesizing chiral 4 and 5 - disubstituted pyrrolidine -2 - ketone skeleton.