225779-44-2

Basic information

• Product Name: H-GLY-TYR-PRO-GLY-GLN-VAL-OH
• Synonyms: GLY-TYR-PRO-GLY-GLN-VAL;H-GLY-TYR-PRO-GLY-GLN-VAL-OH;PROTEINASE ACTIVATED RECEPTOR 4 AGONIST PEPTIDE (GYPGQV), HUMAN;PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN;PAR-4 (1-6) (HUMAN);PAR 4 (1-6);GYPGQV, Coagulation Factor II Receptor-Like 3 (1-6) (huMan), Proteinase Activated Receptor 4 (1-6) (huMan), ThroMbin Receptor-Like 3 (1-6) (huMan);Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt
• CAS NO: 225779-44-2
• Molecular Formula: C28H41N7O9
• Molecular Weight: 619.67
• Mol File: 225779-44-2.mol
• Article Data: 0

Chemical Properties

• Appearance: white to tan/
• Storage Temp.: -15°C
• Solubility: H2O: >2mg/mL
• CAS DataBase Reference: H-GLY-TYR-PRO-GLY-GLN-VAL-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLY-TYR-PRO-GLY-GLN-VAL-OH(225779-44-2)
• EPA Substance Registry System: H-GLY-TYR-PRO-GLY-GLN-VAL-OH(225779-44-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 225779-44-2(Hazardous Substances Data)

Usage

Description

H-GLY-TYR-PRO-GLY-GLN-VAL-OH, also known as PAR4 (1-6), is a peptide agonist of proteinase-activated receptor 4 (PAR4) derived from the amino terminal tethered ligand sequence of human PAR4. It consists of a sequence of eight amino acids, including glycine, tyrosine, proline, glycine, glutamine, and valine. This peptide has the ability to activate PAR4 and its cleavage site mutant PAR4R47A at specific concentrations.

Uses

Used in Pharmaceutical Industry:
H-GLY-TYR-PRO-GLY-GLN-VAL-OH is used as a therapeutic agent for activating PAR4, which plays a crucial role in various physiological processes, including platelet aggregation and blood clotting. It is particularly useful in the development of treatments for conditions related to blood clotting disorders and platelet function.
Used in Research Applications:
In the field of research, H-GLY-TYR-PRO-GLY-GLN-VAL-OH serves as an essential tool for studying the function and regulation of PAR4. It helps researchers understand the receptor's role in platelet aggregation and its potential as a target for therapeutic intervention in various diseases.
Used in Drug Development:
H-GLY-TYR-PRO-GLY-GLN-VAL-OH can be utilized in the development of new drugs targeting PAR4, which may have applications in treating conditions such as thrombosis, atherosclerosis, and other related disorders. By modulating PAR4 activity, these drugs could potentially improve blood clotting and platelet function, offering new treatment options for patients.
Used in Diagnostic Applications:
This peptide agonist can also be employed in the development of diagnostic tools and assays to measure PAR4 activity and its role in various diseases. By understanding how H-GLY-TYR-PRO-GLY-GLN-VAL-OH interacts with PAR4, researchers can create more accurate diagnostic tests to identify and monitor conditions related to blood clotting and platelet function.