22589-46-4

Basic information

• Product Name: methyl 2-(oxiran-2-ylmethoxy)benzoate
• CAS NO: 22589-46-4
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.2106
• Mol File: 22589-46-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.5°C at 760 mmHg
• Flash Point: 141.8°C
• Density: 1.213g/cm³
• Vapor Pressure: 0.000297mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: methyl 2-(oxiran-2-ylmethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(oxiran-2-ylmethoxy)benzoate(22589-46-4)
• EPA Substance Registry System: methyl 2-(oxiran-2-ylmethoxy)benzoate(22589-46-4)

Safety Data

• Hazardous Substances Data: 22589-46-4(Hazardous Substances Data)

Upstream product

• 106-89-8 epichlorohydrin 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 584-08-7 potassium carbonate 

Downstream Products

• 85850-35-7 2-[3-(4-Formyl-piperazin-1-yl)-2-hydroxy-propoxy]-benzoic acid methyl ester 
• 85850-37-9 2-{3-[(1H-Benzoimidazol-2-ylmethyl)-amino]-2-hydroxy-propoxy}-benzoic acid methyl ester 
• 85850-33-5 4-[2-Hydroxy-3-(2-methoxycarbonyl-phenoxy)-propyl]-piperazine-1-carboxylic acid ethyl ester 
• 85850-41-5 2-{2-Hydroxy-3-[2-(5-nitro-pyridin-2-ylamino)-ethylamino]-propoxy}-benzoic acid methyl ester 
• 83356-55-2 2-{3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-benzoic acid methyl ester 
• 38417-81-1 2-[2-Hydroxy-3-(2-hydroxy-1,1-dimethyl-ethylamino)-propoxy]-benzoic acid methyl ester 
• 33947-95-4 methyl 2-[2-Hydroxy-3-(isopropylamino)propoxy]benzoate 
• 51698-60-3 1-(2-methoxycarbonylphenoxy)-2-hydroxy-3-tert.-butylamino propane 
• 85850-26-6 2-{2-Hydroxy-3-[2-(toluene-4-sulfonylamino)-ethylamino]-propoxy}-benzoic acid methyl ester 
• 85850-21-1 2-[3-(2-Acetylamino-ethylamino)-2-hydroxy-propoxy]-benzoic acid methyl ester 
• 85864-51-3 methyl 2-[2-Hydroxy-3-[N-[1,1-dimethyl-2-(aminocarbonylamino)ethyl]amino]propoxy]benzoate 
• 85850-31-3 2-[3-(2-Ethoxycarbonylamino-1,1-dimethyl-ethylamino)-2-hydroxy-propoxy]-benzoic acid methyl ester 
• 85850-49-3 C₁₅H₂₅N₃O₆S 
• 85850-30-2 2-(3-{1,1-Dimethyl-2-[(morpholine-4-carbonyl)-amino]-ethylamino}-2-hydroxy-propoxy)-benzoic acid methyl ester 

Relevant articles and documents

Synthesis, characterization, and anti-inflammatory activities of methyl salicylate derivatives bearing piperazine moiety

In this study, a new series of 16 methyl salicylate derivatives bearing a piperazine moiety were synthesized and characterized. The in vivo anti-inflammatory activities of target compounds were investigated against xylol-induced ear edema and carrageenan-induced paw edema in mice. The results showed that all synthesized compounds exhibited potent anti-inflammatory activities. Especially, the anti-inflammatory activities of compounds M15 and M16 were higher than that of aspirin and even equal to that of indomethacin at the same dose. In addition, the in vitro cytotoxicity activities and anti-inflammatory activities of four target compounds were performed in RAW264.7 macrophages, and compound M16 was found to significantly inhibit the release of lipopolysaccharide (LPS)-induced interleukin (IL)-6 and tumor necrosis factor (TNF)-α in a dose-dependent manner. In addition, compound M16 was found to attenuate LPS induced cyclooxygenase (COX)-2 up-regulation. The current preliminary study may provide information for the development of new and safe anti-inflammatory agents.

Novel compounds

The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Ultra-Short-Acting β-Adrenergic Receptor Blocking Agents. 3. Ethylenediamine Derivatives of (Aryloxy)propanolamines Having Esters on the Aryl Function

Various ethylenediamine derivatives have been incorporated into the nitrogen substituent of certain short-acting (aryloxy)propanolamine systems that contain esters on their aryl functions.Although several of these compounds showed durations of action comparable to their prototypes, most of the nitrogen substituents significantly prolonged the duration of β-adrenergic blockade.Similarly, while one of the compounds showed appreciable cardioselectivity in vitro, generally, little enhancement of cardioselectivity was obtained.A brief discussion of structure-activity relationships observed for the ethylenediamine derivatives is presented.