22596-06-1

Basic information

• Product Name: 1-pentofuranosyl-1H-benzotriazole
• CAS NO: 22596-06-1
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.2386
• Mol File: 22596-06-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 574°C at 760 mmHg
• Flash Point: 300.9°C
• Density: 1.75g/cm³
• Vapor Pressure: 5.15E-14mmHg at 25°C
• Refractive Index: 1.774
• CAS DataBase Reference: 1-pentofuranosyl-1H-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-pentofuranosyl-1H-benzotriazole(22596-06-1)
• EPA Substance Registry System: 1-pentofuranosyl-1H-benzotriazole(22596-06-1)

Safety Data

• Hazardous Substances Data: 22596-06-1(Hazardous Substances Data)

Usage

Structure

A chemical compound consisting of a pentofuranose sugar and a benzotriazole moiety.

Usage

Often used as a building block in the synthesis of nucleoside analogs and pharmaceutical compounds.

Biological Activity

Exhibits antiviral and antitumor activity, making it a potentially useful component in the development of new drugs.

Suitability for Modification

Its structure and properties make it suitable for modification and derivatization to create a variety of analogs with different biological activities.

Importance in Research

Holds promise as an important chemical for further research and development in the field of medicinal chemistry.

Upstream product

• 123499-58-1 1H-benzotriazole mononucleotide ammonium salt 
• 1053637-78-7 C₃₂H₂₂Cl₃N₃O₇ 
• 95-14-7 1,2,3-Benzotriazole 
• 144084-01-5 1-O-acetyl-2,3,5-tris-O-(p-chlorobenzoyl)-β-D-ribofuranose 
• 53-84-9 NAD 
• 15398-66-0 α-guanosine 
• 50730-26-2 tetra-O-acetyl-D-ribofuranose 
• 54548-46-8 (2R,3R,4R,5R)-4-(acetyloxty)-2-[(acetyloxy)methyl]-5-(1H-1,2,3-benzotriazol-1-yl)tetrahydro-3-furanyl acetate 

Relevant articles and documents

Utilization method of waste alpha-1,2,3,5-tetra-O-acetyl-D-ribose in ribose crystalline residual liquid

The invention relates to a method for utilizing waste in ribose crystalline residual liquid. The method comprises the steps that crystalline residual liquid obtained after nucleoside pyrolysis serves as a raw material, an organic layer is extracted, an organic solvent is vaporized and eliminated, mixing is conducted with benzotriazole, under the action of a catalyst, on the condition that the temperature ranges from 100 DEG C to 160 DEG C, a condensation reaction is conducted for 0.33-5.0 h, after the reaction is completed, ethyl acetate is added for dissolving, washing is conducted with water, the solvent is dried out, recrystallization is conducted with diethyl ether, an intermediate product 1-(2,3,5-tri-O-acetyl-beta-D-furanribosyl)benzotriazole is obtained, under the faction of an aminomethanol solution or a sodium methylate methanol solution, acetyl is removed at room temperature, and 1-(2,3,5-tri-hydroxyl-beta-D-furanribosyl)benzotriazole is obtained. The method has the prominent advantages the waste is turned into wealth, at the same time of reducing beta-tetra-O-acetyl-D-ribose crystalline residual liquid, the original waste alpha-tetra-O-acetyl-D-ribose is utilized, and the method has the obvious implement value and social and economic benefits.

Enzymatic ADP-ribosylation of Benzotriazoles and Related Triazoles. Difference of Glycosidation Site between Triazoles and Indazoles

Some benzotriazoles and related triazole were ADP-ribosylated in the presence of NAD and NAD-nucleosidase to give corresponding dinucleotides.The site of ribosylation for these dinucleotides was found exclusively to be N-1 on the basis of their uv and 15N-nmr spectra, contrasting with N-2 for indazole dinucleotides.The origin of this difference in regiochemical specificity between the triazole and diazole systems is discussed.