2261-95-2

Basic information

• Product Name: 5(2H)-Oxazolone, 4-(phenylmethyl)-2-(trifluoromethyl)-
• CAS NO: 2261-95-2
• Molecular Formula: C11H8F3NO2
• Molecular Weight: 243.185
• Mol File: 2261-95-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5(2H)-Oxazolone, 4-(phenylmethyl)-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(2H)-Oxazolone, 4-(phenylmethyl)-2-(trifluoromethyl)-(2261-95-2)
• EPA Substance Registry System: 5(2H)-Oxazolone, 4-(phenylmethyl)-2-(trifluoromethyl)-(2261-95-2)

Safety Data

• Hazardous Substances Data: 2261-95-2(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 407-25-0 trifluoroacetic anhydride 
• 150-30-1 Phenylalanine 

Downstream Products

• 13621-64-2 2-trifluoromethyl-4-(3,3,3-trifluoro-1-phenyl-2-trifluoroacetoxy-propenyl)-2H-oxazol-5-one 
• 111688-33-6 (S)-3-Methyl-2-[(R)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-butyric acid methyl ester 
• 4817-80-5 N-trifluoroacetyl-L-phenylalanyl-L-valine methyl ester 
• 4817-81-6 (S)-1-[3-Phenyl-2-(2,2,2-trifluoro-acetylamino)-propionyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 111609-45-1 (S)-3-Phenyl-2-[(R)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-propionic acid methyl ester 
• 862-21-5 (S)-3-Phenyl-2-[(S)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propionylamino]-propionic acid methyl ester 
• 58219-84-4 5-oxo-7-phenyl-6-(2,2,2-trifluoro-acetylamino)-[1,4]thiazepane-3-carboxylic acid methyl ester 
• 58219-58-2 2-trifluoromethyl-4-benzylidene-Δ²-oxazolin-5-one 
• 58219-88-8 (Z)-2-Amino-3,N-diphenyl-acrylamide 
• 57103-37-4 3-Phenylpyruvanilid-hydrazon 
• 58219-79-7 Z-α-Trifluoracetamidozimtsaeure 
• 58219-80-0 3-Phenyl-2-<(trifluoracetyl)amino>-2-propensaeure-methylester 
• 58219-59-3 (Z)-3,N-Diphenyl-2-(2,2,2-trifluoro-acetylamino)-acrylamide 
• 58219-64-0 3-Phenyl-2-[(Z)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-acryloylamino]-propionic acid methyl ester 

Relevant articles and documents

Selective synthesis of trisubstituted pyrroles through the reactions of alkynyl Fischer carbene complexes with oxazolones

An efficient and simple synthesis of novel trisubstituted 1H-pyrroles 4a-qvia 1,3-dipolar cycloaddition of Δ3-trifluoromethyloxazolones 2a-d with both chromium and tungsten alkynyl Fischer carbene complexes (1a-h) is described. An unexpected and unreported -CF3 group elimination process was observed in the pyrrole structure. Our experimental and theoretical data suggested that the metal fragment may be responsible for this phenomenon. The dipolar cycloaddition proceeded efficiently to produce a single regioisomer, which was unambiguously established through NMR and single-crystal X-ray diffraction studies. Nevertheless, the reaction of alkynyl carbenes bearing an α,β,γ,δ-unsaturated moiety with excess oxazolone 2a produced a polycyclic compound 6 speculatively formed through a cascade reaction involving 1,6-, 1,4- and 1,2-nucleophilic addition steps.

Enantioselective organocatalytic thiol addition to α,β- unsaturated α-amino acid derivatives

A new class of Michael acceptors based on α,β-unsaturated amino acids has been prepared and applied in asymmetric organocatalysis. With the use of thiourea derivatives of cinchona alkaloid-derived catalysts, efficient addition of thiols to the dehydroamin

Gas chromatographic and mass spectrometric characteristics of 2-trifluoromethyl-3-oxazol-5-ones. A potentially useful derivative for α-amino acids

The mass spectra of a number of 2-trifluoromethyl-3-oxazol-5-ones, prepared from protein amino acids, have been recorded. The compounds have been separated by gas chromatography using binary column techniques. Analysis of the mass spectra has identified m