22612-69-7

Basic information

• Product Name: 1-Phenylcyclohexane-1-carbaldehyde
• Synonyms: 1-Phenylcyclohexane-1-carbaldehyde;1-Phenylcyclohexanecarbaldehyde
• CAS NO: 22612-69-7
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 0
• Mol File: 22612-69-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Phenylcyclohexane-1-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylcyclohexane-1-carbaldehyde(22612-69-7)
• EPA Substance Registry System: 1-Phenylcyclohexane-1-carbaldehyde(22612-69-7)

Safety Data

• Hazardous Substances Data: 22612-69-7(Hazardous Substances Data)

Upstream product

• 34877-64-0 2-phenyl-1-oxaspiro[2,5]octane 
• 1608-31-7 (cyclohexylidenemethyl)benzene 
• 2890-42-8 1-phenylcyclohexylcarbonyl chloride 
• 945-49-3 cyclohexylphenylmethanol 
• 1342886-83-2 C₁₃H₁₇BrO 
• 712-50-5 Cyclohexyl phenyl ketone 
• 7500-66-5 (1-bromocyclohexyl)(phenyl)methanone 
• 2043-61-0 cyclohexanecarbaldehyde 
• 140-29-4 phenylacetonitrile 
• 2201-23-2 1-phenyl-1-cyclohexanecarbonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 1135-67-7 1-phenyl-cyclohexanecarboxylic acid 
• 68692-77-3 (1-phenylcyclohexyl)methanol 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 1028282-19-0 2-(Diphenyl-phosphinoyl)-2-methoxy-1-(1-phenyl-cyclohexyl)-ethanol 
• 101498-48-0 1-methoxy-1-(2-phenylcyclohexyl)ethene 
• 166878-44-0 4-benzyl-5-phenyl-3-(1-phenylcyclohexyl)-1,2,4-dioxazolidine 
• 1139694-66-8 1-(1-phenylcyclohexyl)prop-2-yn-1-yl acetate 
• 712-50-5 Cyclohexyl phenyl ketone 
• 68692-77-3 (1-phenylcyclohexyl)methanol 
• 500340-80-7 methanesulfonic acid 1-phenylcyclohexylmethyl ester 
• 32294-72-7 (1-phenylcyclohexyl)acetonitrile 
• 1616922-11-2 9-hydroxy-2-isopropyl-6-(1-phenylcyclohexylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 
• 1616924-37-8 2-(1-phenylcyclohexyl)acetamidine hydrochloride 
• 1616924-38-9 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester 
• 1616924-39-0 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid 
• 1616924-40-3 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide 
• 1616924-41-4 5-benzyloxy-6-hydroxy-2-(1-phenylcyclohexylmethyl)pyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide 

Relevant articles and documents

Kinetic Resolution of Neopentylic Secondary Alcohols by Cu-H-Catalyzed Enantioselective Silylation with Hydrosilanes

A nonenzymatic kinetic resolution of sterically congested alcohols having a quaternary carbon atom in the β-position is reported. The catalyst system CuCl/NaOtBu/(R,R)-Ph-BPE together with a 3,5-xylyl-substituted tertiary hydrosilane enable enantioselective silylation of the hydroxy group. Several alcohols are obtained with good to excellent selectivity factors, and there are no other known straightforward methods to access these motifs.

Selective Aerobic Oxidation of Primary Alcohols to Aldehydes

The 2-azaadamantane- N -oxyl (AZADO)- and 9-azanoradamantane- N -oxyl (nor-AZADO)-catalyzed selective oxidation of primary alcohols to the corresponding aldehydes is described. The use of tert -butyl nitrite as the co-catalyst enables efficient aerobic oxidation in MeCN instead of previously reported AcOH; this is important for the selectivity of the reaction. The addition of a solution of saturated aqueous NaHCO 3 after the completion of the reaction was effective to suppress the overoxidation of the product to the corresponding carboxylic acid during the workup.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.