22618-13-9

Basic information

• Product Name: 2'-METHOXY-3-PHENYLPROPIOPHENONE
• Synonyms: 2'-METHOXY-3-PHENYLPROPIOPHENONE
• CAS NO: 22618-13-9
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 22618-13-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 387.431°C at 760 mmHg
• Flash Point: 172.062°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 2'-METHOXY-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHOXY-3-PHENYLPROPIOPHENONE(22618-13-9)
• EPA Substance Registry System: 2'-METHOXY-3-PHENYLPROPIOPHENONE(22618-13-9)

Safety Data

• Hazardous Substances Data: 22618-13-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O2/c1-18-16-10-6-5-9-14(16)15(17)12-11-13-7-3-2-4-8-13/h2-10H,11-12H2,1H3

Upstream product

• 6948-61-4 (E)-1-(2-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 103-63-9 1-phenyl-2-bromoethane 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 14371-10-9 (E)-3-phenylpropenal 
• 106-94-5 propyl bromide 
• 31600-86-9 2-methoxyphenyllithium 
• 104-53-0 3-phenyl-propionaldehyde 
• 766-51-8 2-Chloroanisole 
• 591-50-4 iodobenzene 
• 58824-49-0 1-(2-methoxyphenyl)prop-2-en-1-ol 
• 579-74-8 2-Methoxyacetophenone 
• 100-51-6 benzyl alcohol 
• 40524-62-7 1-(2-methoxyphenyl)-3-phenyl-2-propene-1-one 
• 5720-06-9 2-Methoxyphenylboronic acid 

Downstream Products

• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 4982-12-1 1-Acetoxy-1-<2-methoxy-benzoyl>-2-phenyl-aethan 
• 20760-12-7 1-(2-hydroxyphenyl)-3-phenyl-1-propanol 
• 13524-55-5 trans-3-Phenyl-1-(2-hydroxy-phenyl)-propen-1 
• 102560-18-9 2-benzyl-1-(2-methoxyphenyl)-3-phenylpropan-1-one 

Relevant articles and documents

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Chemoselective Hydrosilylation of the α,β-Site Double Bond in α,β- And α,β,γ,δ-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol

The B(C6F5)3-catalyzed chemoselective hydrosilylation of α,β- and α,β,γ,δ-unsaturated ketones into the corresponding non-symmetric ketones in mild reaction conditions is developed. Nearly 55 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylated in good to excellent yields. Isotope-labeling studies revealed that hexafluoro-2-propanol also served as a hydrogen source in the process.

Arylation of Aldehydes to Directly Form Ketones via Tandem Nickel Catalysis

A nickel-catalyzed arylation of both aliphatic and aromatic aldehydes proceeds with air-stable (hetero)arylboronic acids, with an exceptionally wide substrate scope. The neutral condition tolerates acidic hydrogen and sensitive polar groups and also preserves α-stereocenters of some chiral aldehydes. Interestingly, this nickel(0) catalysis does not follow common 1,2-insertion of arylmetal species to aldehydes and β-hydrogen elimination.