22618-23-1

Basic information

• Product Name: 3,4-xylyl acetate
• Synonyms: 3,4-xylyl acetate;3,4-Dimethylphenol acetate;Acetic acid 3,4-dimethylphenyl ester;3,4-Dimethylphenyl acetate;4-Acetoxy-o-xylene
• CAS NO: 22618-23-1
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• EINECS: 245-129-5
• Mol File: 22618-23-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 22°C
• Boiling Point: 235°C (estimate)
• Flash Point: 91.5°C
• Appearance: /
• Density: 1.0326 (rough estimate)
• Vapor Pressure: 0.0508mmHg at 25°C
• Refractive Index: 1.5070 (estimate)
• Water Solubility: 10mg/L at 20℃
• CAS DataBase Reference: 3,4-xylyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-xylyl acetate(22618-23-1)
• EPA Substance Registry System: 3,4-xylyl acetate(22618-23-1)

Safety Data

• Hazardous Substances Data: 22618-23-1(Hazardous Substances Data)

Usage

General Description

3,4-xylyl acetate is an organic chemical compound with the formula C10H12O2. It is a colorless liquid with a sweet, floral odor and is often used as a fragrance ingredient in various consumer products such as perfumes, lotions, and air fresheners. It is derived from the aromatic hydrocarbon 3,4-xylene and acetic acid, and is commonly used in the manufacturing of fragrances due to its pleasant scent and stability. Additionally, 3,4-xylyl acetate is also used in the production of dyes, resins, and plasticizers, making it a versatile compound with a wide range of applications in the chemical industry. However, it should be handled with caution as it is flammable and can cause irritation to the skin and eyes.

InChI:InChI=1/C10H12O2/c1-7-4-5-10(6-8(7)2)12-9(3)11/h4-6H,1-3H3

Upstream product

• 95-65-8 3,4-Dimethylphenol 
• 75-36-5 acetyl chloride 
• 28829-84-7 3,4-Dimethyl-4-methyl-4-nitro-2,5-cyclohexadienyl acetate 
• 95-47-6 o-xylene 
• 108-24-7 acetic anhydride 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 201230-82-2 carbon monoxide 
• 74-88-4 methyl iodide 
• 64-19-7 acetic acid 

Downstream Products

• 36436-65-4 2-acetyl-4,5-dimethylphenol 
• 859781-99-0 4-acetoxy-1,2-bis-diacetoxymethyl-benzene 
• 111873-51-9 3,4-dimethyl-6-nitrophenyl acetate 
• 78119-72-9 acetate of α,α,α',α'-tetrabromo-3,4-xylenol 
• 32590-94-6 3,4-dimethyl-4-nitrocyclohexa-2,5-dienone 
• 836-38-4 4-(benzyloxy)-1,2-dimethylbenzene 
• 111726-44-4 4-Methoxymethoxy-1,2-dimethyl-benzene 
• 229177-48-4 tert-butyl(3,4-dimethylphenoxy)dimethylsilane 
• 95-65-8 3,4-Dimethylphenol 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 78119-81-0 6-Hydroxy-2-phenyl-benzo[f]isoindole-1,3-dione 
• 20769-30-6 4-hydroxy-ortho-phthalaldehyde 
• 91969-74-3 2'-methoxy-4',5'-dimethylacetophenone 
• 91061-36-8 2-methoxy-4,5-dimethylbenzoic acid 

Relevant articles and documents

Synthesis and characterization of (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol from 2-hydroxy-4,5-dimethylacetophenone

This study reports the development of a novel substituted hydrazone prepared from 2-hydroxy-4,5-dimethylacetophenone and hydrazine in alkaline medium at controlled conditions which yields as corresponding hydrazone [(E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol]. The structure of synthesized (E)-2-(1-hydrazonoethyl)-4,5-dimethylphenol was elucidated by elemental analysis and spectroscopic techniques like infrared spectroscopy, ultraviolet–visible spectroscopy, high-performance liquid chromatography, proton nuclear magnetic resonance and mass spectrum.

An efficient method to prepare aryl acetates by the carbonylation of aryl methyl ethers or phenols

Synthesis of valuable chemicals from lignin based compounds is critical for the application of biomass. Here, we develop a method of preparing aryl acetates by the carbonylation of aryl methyl ethers or phenols under low CO pressure. Good to excellent yields of aryl acetates were obtained using different substrates, and a possible reaction mechanism was proposed by conducting a series of control experiments. This method may provide a potential way for the utilization of lignin.

Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates

Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.