22618-48-0

Basic information

• Product Name: 1-(cyclohex-1-en-1-yl)-2-methoxybenzene
• CAS NO: 22618-48-0
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.2655
• Mol File: 22618-48-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 296.6°C at 760 mmHg
• Flash Point: 115.1°C
• Density: 1.012g/cm³
• Vapor Pressure: 0.00251mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 1-(cyclohex-1-en-1-yl)-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclohex-1-en-1-yl)-2-methoxybenzene(22618-48-0)
• EPA Substance Registry System: 1-(cyclohex-1-en-1-yl)-2-methoxybenzene(22618-48-0)

Safety Data

• Hazardous Substances Data: 22618-48-0(Hazardous Substances Data)

Usage

General Description

1-(cyclohex-1-en-1-yl)-2-methoxybenzene is a chemical compound that falls into the category of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. This specific chemical is characterized by a cyclohexene ring (a six-carbon ring containing one double bond) attached to a benzene ring that also has a methoxy group attached (a oxygen-single-bonded-to-a-carbon group, where that carbon is also bonded to three hydrogens). The physical properties are still largely unknown as it's quite a specialized compound, often synthesized for research purposes in the field of synthetic organic chemistry. Its applications have not been widely documented, but such chemicals often find uses in perfumery, creating pharmaceuticals, or building complex organic materials.

Upstream product

• 578-57-4 2-bromoanisole 
• 108-94-1 cyclohexanone 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 109467-74-5 phosphoric acid cyclohex-1-enyl ester diphenyl ester 
• 22524-46-5 cyclohex-1-en-1-yl 4-methylbenzenesulfonate 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 2044-08-8 1-bromocyclohex-1-ene 
• 16463-34-6 potassium 2-methoxybenzoate 
• 579-75-9 2-Methoxybenzoic acid 
• 79416-02-7 1-(o-methoxyphenyl)cyclohexanol 

Downstream Products

• 854913-24-9 2-(2-methoxy-phenyl)-cyclohex-2-enol 
• 129353-33-9 1-(2'-Methoxyphenyl)-7-methylenebicyclo<4.1.0>heptane 
• 137273-41-7 2-(2-methoxyphenyl)cyclohex-2-enone 
• 1269246-97-0 6-benzyloxy-1-(2-methoxyphenyl)cyclohexene 
• 1321159-54-9 6-(4-nitrophenylamino)-1-(2-methoxyphenyl)cyclohexene 
• 58713-52-3 2'-methoxy-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 

Relevant articles and documents

Enantiopure cis- and trans-2-(2-Aminocyclohexyl)phenols: Effective Preparation, Solid-State Characterization, and Application in Asymmetric Organocatalysis

Effective synthesis of cis- and trans-2-(2-methoxyphenyl)cyclohexylamine as well as their multigram-scale optical resolution by diastereomeric salt formation with dibenzoyl tartaric acid have been described. Assignment of absolute configurations to the enantiomers has been made by X-ray crystallography. Starting from the resolved precursor, diverse aminoalkylphenols (AAPs) having primary, secondary, and tertiary amine group as well as a quaternary ammonium phenol have been prepared as potential bifunctional organocatalysts based on the cyclohexane backbone. We furthermore report herein that AAPs carrying a primary amine and a phenolic hydroxyl group can catalyze the direct aldol reaction with high activity and setereoselectivity, and thus up to 97 % yield, 90:10 syn/anti diastereomeric ratio, and 80 % enantiomeric excess can be achieved.

N-heterocyclic carbene dichotomy in Pd-catalyzed acylation of aryl chlorides via C-H bond functionalization

The first Pd-catalyzed intramolecular acylation of aryl chlorides via C-H bond functionalization is presented. The method allows for the synthesis of a variety of elusive benzocyclobutenones with a wide range of functional groups and substitution patterns. We demonstrate that a change in the ligand backbone dictates the selectivity pattern.

FeCl3/Nal-catalyzed allylic C-H oxidation of arylalkenes with a catalytic amount of disulfide under air

This paper describes a FeCl3/NaI-catalyzed formal allylic C-H oxidation of arylalkenes using a catalytic amount of disulfide with BnOH and 4-nitroaniline as nucleophiles and air as oxidant to form the corresponding allyl ethers and amines. A possible reaction mechanism has been proposed.