2262-07-9

Basic information

• Product Name: Benzene, [(2,2,2-trifluoroethyl)thio]-
• CAS NO: 2262-07-9
• Molecular Formula: C8H7F3S
• Molecular Weight: 192.205
• Mol File: 2262-07-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, [(2,2,2-trifluoroethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(2,2,2-trifluoroethyl)thio]-(2262-07-9)
• EPA Substance Registry System: Benzene, [(2,2,2-trifluoroethyl)thio]-(2262-07-9)

Safety Data

• Hazardous Substances Data: 2262-07-9(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 14897-48-4 S-(2,2,2-trifluoroethyl) ethanethioate 
• 5296-64-0 allyl phenyl thioether 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 5848-60-2 cinnamyl(phenyl)sulfide 
• 5651-88-7 phenyl propargyl sulfide 
• 108-98-5 thiophenol 
• 75-89-8 2,2,2-trifluoroethanol 
• 831-91-4 Benzyl phenyl sulfide 
• 421-04-5 1-chloro-1,1,2-trifluoroethane 
• 931-59-9 benzenesulfenyl chloride 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 421-06-7 2-bromo-1,1,1-trifluoroethane 

Downstream Products

• 108200-50-6 Phenyl 1-acetoxy-2,2,2-trifluoroethyl sulfide 
• 1414925-90-8 (E)-1-bromo-4-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1418141-40-8 C₁₈H₁₇F₃O₃S 
• 1414925-89-5 (E)-1-methyl-2-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1414925-88-4 (E)-1-methyl-4-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1402748-62-2 (E)-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1402748-78-0 (E)-(1-phenyl-4-(trifluoromethyl)hepta-1,6-dien-4-ylsulfonyl)benzene 
• 1414925-94-2 1-methyl-4-((1E,6E)-7-phenyl-4-(phenylsulfonyl)-4-(trifluoromethyl)hepta-1,6-dienyl)benzene 
• 1402748-84-8 ((1E,6E)-4-(phenylsulfonyl)-4-(trifluoromethyl)hepta-1,6-diene-1,7-diyl)dibenzene 
• 1414925-93-1 (E)-1-nitro-4-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1414925-92-0 (E)-1-chloro-4-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 1414925-91-9 (E)-1-fluoro-4-(5,5,5-trifluoro-4-(phenylsulfonyl)pent-1-enyl)benzene 
• 110855-45-3 benzyl 4-(2,2,2-trifluoroethylthio)phenyl ketone 
• 129286-52-8 2,2,2-trifluoro-1-(4-phenethylphenyl)ethyl phenyl sulfide 

Relevant articles and documents

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Synthesis of aryl 2,2,2-trifluoroethyl sulfides

Aryl 2,2,2-trifluoroethyl sulfides were synthesized by copper(I)-catalyzed nucleophilic aromatic substitution reaction (Goldberg-Ullmann coupling). The method requires aryl iodides and 2,2,2-trifluoroethyl thioacetate as starting materials, benzylamine as solvent and base, and copper(I) bromide as a catalyst. The reaction mixture was stirred at 110 °C for 6 h under inert atmosphere to afford the targeted aryl 2,2,2-trifluoroethyl sulfides in moderate to good yield.

New sulfuryl fluoride-derived alkylating reagents for the 1,1-dihydrofluoroalkylation of thiols

Herein, we report a new method for the one-pot synthesis of 1,1-dihydrofluoroalkyl sulfides by bubbling sulfuryl fluoride (SO2F2) through a solution of the corresponding alcohol and thiol. The reaction proceeds through a new class of bis(1,1-dihydrofluoroalkyl) sulfate reagents, to afford the desired 1,1-dihydrofluoroalkyl sulfides in 55-90% isolated yields. The bis(1,1-dihydrofluoroalkyl) sulfates are highly chemoselective for thiol alkylation, and are unreactive with competing, unprotected nucleophiles, including amines, alcohols, and carboxylic acids.

Dealkylative intercepted rearrangement reactions of sulfur ylides

Sulfur ylides are well-known to undergo sigmatropic rearrangement reaction. Herein, we describe a novel reactivity of sulfur ylides, which provides access to the product of a formal functional group metathesis upon dealkylative interception of the rearrangement process. Using a simple iron catalyst and in situ generated diazoalkanes this method provides access to α-mercaptoacetonitrile derivatives.