22649-30-5Relevant articles and documents
Design of High-Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface
Alontaga, Aileen Y.,Li, Yifei,Chen, Chih-Hong,Ma, Chen-Ting,Malany, Siobhan,Key, Danielle E.,Sergienko, Eduard,Sun, Qing,Whipple, David A.,Matharu, Daljit S.,Li, Baozong,Vega, Ramir,Li, Yi-Jia,Schoenen, Frank J.,Blagg, Brian S. J.,Chung, Thomas D.Y.,Chen, Yuan
, p. 239 - 246 (2015)
Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multidisciplinary approach to identify small-molecule disruptors of protein-protein interactions that are mediated by SUMO (small
Synthesis, Activity, and Molecular Modeling Studies of Novel Human Aldose Reductase Inhibitors Based on a Marine Natural Product
De La Fuente, Jesús ángel,Manzanaro, Sonia,Martín, María Jesús,De Quesada, Teresa G.,Reymundo, Isabel,Luengo, Santos M.,Gago, Federico
, p. 5208 - 5221 (2007/10/03)
Aldose reductase (ALR2) has been implicated in the etiology of diabetic complications, including blindness. Because of the limited number of currently available drugs for the prevention of these long-term complications, the discovery of new ALR2 inhibitor
