22656-00-4Relevant articles and documents
Enantioselective iridium-catalyzed allylic alkylation of racemic branched alkyl-substituted allylic acetates with malonates
Zhang, Tian-Yuan,Deng, Yi,Wei, Kun,Yang, Yu-Rong
supporting information, p. 1086 - 1089 (2021/02/06)
The regio- and enantioselective allylic substitution of branched alkyl-substituted allylic acetates employing malonates has been achieved through a process that calls for Krische's πallyliridium C,O-benzoate catalyst. The protocol reported herein can be applied to a diverse set of branched alkyl substrates that are generally not well tolerated in the other two types of Ir-catalyzed allylation.
Regioselective Acetoxylation of Terminal Olefins Using a Palladium(II)–Thiadiazole Catalyst
Li, Xiaohan,Sun, Bin,Zhou, Jiadi,Jin, Can,Yu, Chuangming
supporting information, p. 2635 - 2638 (2019/04/04)
First-time use of a palladium(II)–thiadiazole catalyst in the allylic oxidation of terminal olefins to linear allylic acetates. Employing this strategy, a range of allylic esters (20 examples) were synthesized in 43 % to 80 % yield with excellent regio- and stereoselectivities.
Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: A case of clofilium analogues
Louvel, Julien,Carvalho, Jo?o F.S.,Yu, Zhiyi,Soethoudt, Marjolein,Lenselink, Eelke B.,Klaasse, Elisabeth,Brussee, Johannes,Ijzerman, Adriaan P.
, p. 9427 - 9440 (2014/01/06)
Cardiotoxicity is a side effect that plagues modern drug design and is very often due to the off-target blockade of the human ether-à-go-go related gene (hERG) potassium channel. To better understand the structural determinants of this blockade, we design
