22668-01-5 Usage
Description
ETANIDAZOLE, also known as Radinyl, is a monocarboxylic acid amide derived from the formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. It is primarily recognized for its role as a hypoxic radiosensitizer, which means it enhances the sensitivity of tumor cells to radiation therapy, particularly in hypoxic conditions.
Used in Antineoplastic Applications:
ETANIDAZOLE is used as a hypoxic cell radiosensitizer for enhancing the effectiveness of radiation therapy in treating various types of cancer. It works by increasing the sensitivity of hypoxic tumor cells to radiation, leading to improved treatment outcomes.
Used in Glioma Treatment:
In the field of oncology, ETANIDAZOLE is used as an adjuvant to Paclitaxel (P132500) for the treatment of glioma, a type of brain cancer. The combination of these two drugs aims to improve the therapeutic response and overall patient outcomes.
Used in Ovarian Cancer Treatment:
ETANIDAZOLE is also utilized in conjunction with Carboplatin (C177500) for the treatment of advanced ovarian cancer. The synergistic effect of these drugs helps in sensitizing the cancer cells to radiation, thereby increasing the effectiveness of the treatment.
Used in Pharmaceutical Industry:
ETANIDAZOLE, under the brand name Radinyl, is used as a radiosensitizing agent specifically designed for hypoxic tumor cells. Its application in the pharmaceutical industry is focused on enhancing the efficacy of radiation therapy in cancer treatment, making it a valuable asset in the fight against cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 22668-01-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,6,6 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 22668-01:
(7*2)+(6*2)+(5*6)+(4*6)+(3*8)+(2*0)+(1*1)=105
105 % 10 = 5
So 22668-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N4O4/c12-4-2-8-6(13)5-10-3-1-9-7(10)11(14)15/h1,3,12H,2,4-5H2,(H,8,13)
22668-01-5Relevant articles and documents
Synthesis and fluorescent characteristics of imidazole-indocyanine green conjugates
Pavlik, Christopher,Biswal, Nrusingh C.,Gaenzler, Faith Corbo,Morton, Martha D.,Kuhn, Liisa T.,Claffey, Kevin P.,Zhu, Quing,Smith, Michael B.
experimental part, p. 9 - 15 (2011/07/07)
We have successfully synthesized imidazole-dye conjugates by linking imidazole and nitroimidazoleacetic acids to an indocyanine green (ICG) carboxylic acid derivative, using an ethanolamine linker. These dye-conjugates show absorbance peaks at 754-756 nm and fluorescence peaks at 780 nm. The dye-conjugates show a blue shift of 25 nm and 30 nm in the absorption and fluorescence spectra respectively when compared to that of standard cardiogreen. There is no change in absorption and fluorescence spectral profiles between the ICG derivative and imidazole conjugates. The extinction coefficients of new ICG derivative and imidazole conjugates are 1.8 times higher than that of standard ICG. The relative quantum yields of the new compounds are 4.5-5.5 times higher than that of the Sigma-Aldrich's ICG. The dyes are tested for hypoxia in-vitro with 4T1 luc cell lines and it is found that the cells treated with 2-nitroimidazole ICG show a contrast of fluorescence signal of 2.5-3.0 for the cells under hypoxic to that of cells under normoxic. However pure ICG shows no significant difference between hypoxic and normoxic cells.
