22669-27-8

Basic information

• Product Name: 4-AMINOBENZOIC ACID HCL
• Synonyms: 4-AMINOBENZOIC ACID HCL;4-Aminobenzoic acid hydrochloride
• CAS NO: 22669-27-8
• Molecular Formula: C₇H₇NO₂*ClH
• Molecular Weight: 173.6
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 22669-27-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMINOBENZOIC ACID HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOBENZOIC ACID HCL(22669-27-8)
• EPA Substance Registry System: 4-AMINOBENZOIC ACID HCL(22669-27-8)

Safety Data

• Hazardous Substances Data: 22669-27-8(Hazardous Substances Data)

Usage

General Description

4-Aminobenzoic acid HCl, also known as p-aminobenzoic acid hydrochloride, is a compound that consists of a benzene ring with a carboxylic acid group and an amino group attached to it. It is commonly used in the production of local anesthetics and sunscreens, as well as in the synthesis of certain dyes and pharmaceuticals. This chemical is often utilized as a precursor in the manufacturing of various industrial and commercial products, and it plays a crucial role in the pharmaceutical and cosmetic industries. The hydrochloride salt form of 4-Aminobenzoic acid is soluble in water and has a white crystalline appearance, making it suitable for a wide range of applications.

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 62-23-7 4-nitro-benzoic acid 
• 28533-43-9 4-formamidobenzoic acid 
• 824-72-6 P,P-dichlorophenylphosphine oxide 

Downstream Products

• 65568-72-1 5,5'-bis-(4-carboxy-phenyl)-1,1'-hexanediyl-bis-biguanide; dihydrochloride 
• 7366-56-5 4-thioureidobenzoic acid 
• 285556-33-4 4-((imino(methylthio)methyl)amino)benzoic acid 
• 5429-03-8 4-(2-carbamoylsulfanyl-acetylamino)-benzoic acid 
• 55842-27-8 4,4'-triazene-1,3-diyl-di-benzoic acid 
• 117043-11-5 4-(dichlorophosphoryl-amino)-benzoic acid 
• 100142-85-6 4-(4,5-dimethyl-thiazol-2-ylamino)-benzoic acid 
• 3729-21-3 4-isocyanatobenzoic acid chloride 
• 7496-53-9 4-glycylamino-benzoic acid 
• 23961-21-9 4-phenylalanylamino-benzoic acid 
• 62600-84-4 alanine-4-aminobenzoic acid 
• 23961-09-3 4-5-Benzyl-L-glutamylamino>-benzoesaeure 
• 89393-96-4 1-(p-carboxyphenyl)-3-phenyl-5-(2-benzothiazolyl)formazan 
• 129884-95-3 1-(4-methoxycarbonylphenylimino)-2-phenyl-3-(4-carboxyphenylamino)indene potassium salt 

Relevant articles and documents

Synthesizing method of flame-retardant agent bis-(para-carboxy phenylamino)phenyl phosphine oxide

The invention relates to an improved synthesizing method of a flame-retardant agent bis-(para-carboxy phenylamino)phenyl phosphine oxide. The improved synthesizing method comprises the following stepsof dissolving para aminobenzoic acid into a 1,4-dioxane

The ortho effect on the acidic and alkaline hydrolysis of substituted formanilides

The kinetics of formanilides hydrolysis were determined under first-order conditions in hydrochloric acid (0.01-8 M, 20-60°C) and in hydroxide solutions (0.01-3 M, 25 and 40°C). Under acidic conditions, second-order specific acid catalytic constants were used to construct Hammett plots. The ortho effect was analyzed using the Fujita-Nishioka method. In alkaline solutions, hydrolysis displayed both first- and second-order dependence in the hydroxide concentration. The specific base catalytic constants were used to construct Hammett plots. Ortho effects were evaluated for the first-order dependence on the hydroxide concentration. Formanilide hydrolyzes in acidic solutions by specific acid catalysis, and the kinetic study results were consistent with the AAC2 mechanism. Ortho substitution led to a decrease in the rates of reaction due to steric inhibition of resonance, retardation due to steric bulk, and through space interactions. The primary hydrolytic pathway in alkaline solutions was consistent with a modified BAC2 mechanism. The Hammett plots for hydrolysis of meta- and para-substituted formanilides in 0.10 M sodium hydroxide solutions did not show substituent effects; however, ortho substitution led to a decrease in rate constants proportional to the steric bulk of the substituent.

Synthesis of dye from anthranilic acid and its utility

A new dye was synthesized from anthranilic acid by conversion of p-amino benzoic acid to HCl salt of ammonium benzoyl chloride. Condensation of HCl salt of ammonium benzoyl chloride with anthranilic acid at various conditions viz., temperature, condition