226717-83-5 Usage
General Description
2,3,5-Trifluorobenzyl bromide is a chemical compound with the formula C7H4BrF3 that is frequently used in organic synthesis as a benzyl protecting group for alcohols and amines. It is a clear, colorless liquid with a strong, pungent odor, and is highly reactive due to the presence of the bromine substituent. It is commonly used in the pharmaceutical industry and in the production of agrochemicals and industrial chemicals. 2,3,5-Trifluorobenzyl bromide is a highly flammable and corrosive substance that should be handled with care and stored in a cool, dry place away from heat and direct sunlight.
Check Digit Verification of cas no
The CAS Registry Mumber 226717-83-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,6,7,1 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 226717-83:
(8*2)+(7*2)+(6*6)+(5*7)+(4*1)+(3*7)+(2*8)+(1*3)=145
145 % 10 = 5
So 226717-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrF3/c8-3-4-1-5(9)2-6(10)7(4)11/h1-2H,3H2
226717-83-5Relevant articles and documents
General synthetic pathway to oxygenated 3-methylbenz[g]isoquinoline- 5,10-diones
Krapcho, A. Paul,Waterhouse, David J.
, p. 737 - 750 (2007/10/03)
The synthesis of naturally occurring dioxygenated and trioxygenated 3- methylbenz[g]isoquinoline-5,10-diones has been accomplished. The critical step involved regioselective additions of di- or trifluorobenzylzinc bromides to activated methyl 6-methylnicotinate. Aromatizations of the resultant dihydropyridines followed by hydrolysis led to the corresponding benzylpyridinecarboxylic acids which on annulative-oxidations led to the respective difluoro- or trifluorobenz[g]isoquinoline-5,10-diones. Displacements of fluorides by methoxide led to the di- or trimethoxy analogues which on selective demethylations led to bostrycoidin, 8-O- methylbostrycoidin, tolypocladin, 5-deoxybostrycoidin or 5-deoxy-6-O-methyl- bostrycoidin. The synthesis of isobostrycoidin and isotolypocladin has also been accomplished.
