22686-81-3

Basic information

• Product Name: 3-methyl-2-phenylquinazolin-4(3H)-one
• CAS NO: 22686-81-3
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 22686-81-3.mol
• Article Data: 65

Chemical Properties

• Boiling Point: 396.2°C at 760 mmHg
• Flash Point: 193.4°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.74E-06mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3-methyl-2-phenylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-phenylquinazolin-4(3H)-one(22686-81-3)
• EPA Substance Registry System: 3-methyl-2-phenylquinazolin-4(3H)-one(22686-81-3)

Safety Data

• Hazardous Substances Data: 22686-81-3(Hazardous Substances Data)

Upstream product

• 18543-22-1 2-benzoylaminobenzamide 
• 127082-54-6 2-Benzamido-N-methylbenzamide 
• 21737-87-1 N-methyl benzimidoyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 76893-90-8 (N-methyl)(phenyl)carbonitrilium trifluoromethylsulfonate 
• 28144-70-9 anthranilic acid amide 
• 100-46-9 benzylamine 
• 3400-29-1 N-methyl-2-nitrobenzamide 
• 16285-32-8 2,3-dihydro-3-methyl-2-phenylquinazolin-4(1H)-one 
• 593-51-1 methylamine hydrochloride 
• 7510-49-8 methyl 2-(benzamido)benzoate 
• 110809-98-8 2-Amino-benzoic acid N-methyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 123-75-1 pyrrolidine 
• 118-48-9 isatoic anhydride 

Downstream Products

• 52458-01-2 4,4-di-naphthalen-1-yl-2-phenyl-4H-benzo[d][1,3]oxazine 
• 7031-95-0 1-benzoxy-2,2,6,6-tetramethylpiperidine 

Relevant articles and documents

Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)?H/N?H Cross-Coupling Mediated by I2/DMSO

A novel approach for the synthesis of 2-arylquinazolin-4(3H)-ones was developed. A series of title compounds were obtained with good functional group tolerance and good yields by I2/DMSO-mediated intramolecular oxidative cross-coupling of 2-(benzylamino)benzamides to form C=N double bonds. This method was applicable for gram-scale synthesis. A proposed reaction pathway based on some control experiments was also provided.

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.

Complementary Reactivity in Selective Radical Processes: Electrochemistry of Oxadiazolines to Quinazolinones

Electrochemistry has recently emerged as a sustainable approach for efficiently generating radical intermediates utilizing eco-friendly electric energy. An electrochemical process was developed to transform 1,2,4-oxadiazolines under mild conditions. The electrochemical N-O bond cleavage at a controlled oxidation potential led to the selective synthesis of quinazolinone derivatives that could not be obtained by photocatalytic radical processes, indicating complementary reactivities in radical processes. The electrochemical reaction pathways were fully revealed by density functional theory-based investigations.