226920-44-1

Basic information

• Product Name: 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione
• Synonyms: 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione
• CAS NO: 226920-44-1
• Molecular Weight: 307.349
• Mol File: 226920-44-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione(226920-44-1)
• EPA Substance Registry System: 2-(5-oxo-5-phenylpentyl)isoindole-1,3-dione(226920-44-1)

Safety Data

• Hazardous Substances Data: 226920-44-1(Hazardous Substances Data)

Upstream product

• 16717-64-9 1-azidostyrene 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 71-43-2 benzene 
• 136918-14-4 phthalimide 
• 942-93-8 5-Chloro-1-phenyl-1-pentanone 
• 1575-61-7 5-Chlorovaleroyl chloride 
• 5428-09-1 3-phthalimido-1-propene 
• 226920-42-9 O-ethyl S-4-oxo-4-phenyl-1-phthalimidomethylbutyl dithiocarbonate 

Downstream Products

• 82902-45-2 1-benzoyl-2-phenylpiperidine 
• 3466-80-6 2-phenylpiperidine 
• 57050-07-4 2-phenyl-3,4,5,6-tetrahydropyridine 

Relevant articles and documents

Vinyl Azides as Radical Acceptors in the Vitamin B12-Catalyzed Synthesis of Unsymmetrical Ketones

Vinyl azides are very reactive species and as such are useful building blocks, in particular, in the synthesis of N-heterocycles. They can also serve as precursors of ketones. These form in reactions of vinyl azides with nucleophiles or radicals. We have found, however, that under light irradiation vitamin B12 catalyzes the reaction of vinyl azides with electrophiles to afford unsymmetrical carbonyl compounds in decent yields. Mechanistic studies revealed that alkyl radicals are key intermediates in this transformation.

A flexible, convergent approach to piperidines, pyridines, azepines, and related derivatives

A highly convergent approach has been developed for the construction of various nitrogen heterocycles using as the key step the intermolecular addition of an α-ketonyl radical onto a suitably protected allylic or homoallylic amine.