227184-97-6

Basic information

• Product Name: 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester
• Synonyms: 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester
• CAS NO: 227184-97-6
• Molecular Weight: 360.453
• Mol File: 227184-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester(227184-97-6)
• EPA Substance Registry System: 1-(4-isobutyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl-carbamic acid benzyl ester(227184-97-6)

Safety Data

• Hazardous Substances Data: 227184-97-6(Hazardous Substances Data)

Upstream product

• 7801-71-0 N-benzyloxycarbonyl-L-leucyl-L-leucine 

Downstream Products

• 328-39-2 LEUCINE 
• 125815-90-9 (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid 2-cyano-ethyl ester 
• 58889-73-9 (S)-N-benzyloxycarbonyl-leucine ethyl ester 
• 51021-87-5 N-benzyloxycarbonyl-L-leucine methyl ester 

Relevant articles and documents

A rapid reaction releasing the carboxyl terminal residues of peptides

Alcoholysis of peptide oxazolones in alcohols containing dilute acid, such as 0.02M HCl, gives the C-terminal amino acid and the ester of the shortened peptide within 10 minutes at room temperature in 30-70% yields. This together with the finding that the peptide oxazolones can be formed within 3 minutes with alkylchloroformates enables the rapid removal of peptide C-terminal residues.