227305-69-3 Usage
Description
2,3-Dihydrobenzo[b]furan-5-boronic acid is an organic compound characterized by a white to light yellow crystalline powder. It features a benzofuran ring structure with a boronic acid group attached at the 5-position, which endows it with unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2,3-Dihydrobenzo[b]furan-5-boronic acid is used as a key intermediate in the synthesis of halogenated nucleosides for the pharmaceutical industry. Its boronic acid functionality plays a crucial role in the Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with halide-containing nucleoside precursors. This process is vital for the development of novel antiviral and anticancer drugs, as halogenated nucleosides often exhibit enhanced biological activity and selectivity.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3-dihydrobenzo[b]furan-5-boronic acid serves as a versatile building block for the construction of various complex organic molecules. Its reactivity in palladium-catalyzed cross-coupling reactions allows for the efficient formation of new carbon-carbon bonds, facilitating the synthesis of a wide range of bioactive compounds, natural products, and pharmaceutical agents.
Used in Materials Science:
2,3-Dihydrobenzo[b]furan-5-boronic acid also finds applications in materials science, where its unique structural features and boronic acid functionality can be exploited to design and synthesize novel materials with tailored properties. These materials may have potential uses in areas such as sensors, catalysts, and functional coatings, owing to their ability to form reversible covalent bonds with a variety of substrates.
Check Digit Verification of cas no
The CAS Registry Mumber 227305-69-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,7,3,0 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 227305-69:
(8*2)+(7*2)+(6*7)+(5*3)+(4*0)+(3*5)+(2*6)+(1*9)=123
123 % 10 = 3
So 227305-69-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H9BO3/c10-9(11)7-1-2-8-6(5-7)3-4-12-8/h1-2,5,10-11H,3-4H2
227305-69-3Relevant articles and documents
Multiple C-H activations to construct biologically active molecules in a process completely free of organohalogen and organometallic components
Li, Bi-Jie,Tian, Shi-Liang,Fang, Zhao,Shi, Zhang-Jie
, p. 1115 - 1118 (2008/09/21)
(Chemical Equation Presented) Step by step: Highly selective cross dehydrogenase arylation of acetanilides was developed to construct biaryls under mild condition. With this method, different aryl C-H bonds were activated in sequential reactions to construct functionalized carbazoles (see scheme), which are present as key structural units in various biological molecules and organic optical materials.
