2274-42-2

Basic information

• Product Name: METHYLSULFONYLACETONITRILE
• Synonyms: 2-(METHYLSULFONYL)ACETONITRILE;Methylsulphonylacetonitrile;mesylacetonitrile;2-(Methylsulphonyl)acetonitrile;Methanesulfonylacetonitrile,98+%;Methanesulphonylacetonitrile,98+%;Methylsulfonylacetonitrile, 98+%;Methylsufonylacetonitrile
• CAS NO: 2274-42-2
• Molecular Formula: C₃H₅NO₂S
• Molecular Weight: 119.14
• EINECS: 218-888-5
• Product Categories: Aliphatics;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 2274-42-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 81-84 °C(lit.)
• Boiling Point: 360.6°Cat760mmHg
• Flash Point: 171.9°C
• Appearance: White to off-white/Powder or Crystalline Powder
• Density: 1.288g/cm³
• Vapor Pressure: 2.2E-05mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• BRN: 969929
• CAS DataBase Reference: METHYLSULFONYLACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLSULFONYLACETONITRILE(2274-42-2)
• EPA Substance Registry System: METHYLSULFONYLACETONITRILE(2274-42-2)

Safety Data

• Hazard Codes: Xn,T
• Statements: 20/21/22
• Safety Statements: 22-26-36
• RIDADR: UN 3439 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 2274-42-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 2274-42-2 differently. You can refer to the following data:
1. Methylsulfonylacetonitrile is used in preparation of substituted pyrimidinylamino isoquinoline and naphthyridine compounds as inhibitors of mutant forms of EGFR.
2. (Methylsulfonyl)acetonitrile was used in the synthesis of:substituted δ-pyrone ring analogues 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position

InChI:InChI=1/C3H5NO2S/c1-7(5,6)3-2-4/h3H2,1H3

Upstream product

• 35120-10-6 methylthioacetonitrile 
• 20277-69-4 sodium methansulfinate 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 24146-38-1 2-Methylsulfonylmethylen-thiazolidon-(4) 
• 106073-27-2 3-(dimethylamino)-2-(methylsulfonyl)-2-propenenitrile 
• 104007-26-3 3-ethoxy-2-methylsulfonyl propenenitrile 
• 118986-48-4 (Z)-2-Methanesulfonyl-5-phenyl-pent-2-enenitrile 
• 62020-09-1 Methyl α-(methylsulfonyl)acetate 
• 77444-87-2 1-Cyclohexyl-3-methanesulfonyl-4,5-dimethyl-1H-pyrrol-2-ylamine 
• 77444-88-3 1-Benzyl-2-amino-3-methylsulfonyl-4,5-dimethylpyrrole 
• 83677-23-0 (Z)-3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-methanesulfonyl-acrylonitrile 

Relevant articles and documents

Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid

Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline and the second messenger nitric oxide. Three mechanistic pathways are proposed for the inactivation of neuronal NOS (nNOS) by (S)-2-amino-5-(2-(methylthio)acetimidamido)pentanoic acid (1): sulfide oxidation, oxidative dethiolation, and oxidative demethylation. Four possible intermediates were synthesized. All compounds were assayed with nNOS, their IC50, KI, and kinact values were obtained, and their crystal structures were determined. The identification and characterization of the products formed during inactivation provide evidence for the details of the inactivation mechanism. On the basis of these studies, the most probable mechanism for the inactivation of nNOS involves oxidative demethylation with the resulting thiol coordinating to the cofactor heme iron. Although nNOS is a heme-containing enzyme, this is the first example of a NOS that catalyzes an S-demethylation reaction; the novel mechanism of inactivation described here could be applied to the design of inactivators of other heme-dependent enzymes.

Inhibitors of the advanced glycosylation of proteins and methods of use therefor

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents

Aminomethyl oxooxazolidinyl ethenylbenzene derivatives, including the nitriles, sulfoxides, acetamides and nitro compounds, such as l-N-[3-[4-(E-1-methyl-2-cyanoethenyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.