2274-50-2

Basic information

• Product Name: 2-[(1-carboxyethyl)amino]benzoic acid
• CAS NO: 2274-50-2
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.1986
• Mol File: 2274-50-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 472.4°C at 760 mmHg
• Flash Point: 239.5°C
• Density: 1.399g/cm³
• Vapor Pressure: 9.95E-10mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 2-[(1-carboxyethyl)amino]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1-carboxyethyl)amino]benzoic acid(2274-50-2)
• EPA Substance Registry System: 2-[(1-carboxyethyl)amino]benzoic acid(2274-50-2)

Safety Data

• Hazardous Substances Data: 2274-50-2(Hazardous Substances Data)

Usage

General Description

2-[(1-carboxyethyl)amino]benzoic acid, also known as acecarbromal, is a compound that belongs to the class of organic compounds known as benzoic acids. It is commonly used as a local anesthetic and is often administered in the form of eye drops to alleviate ocular pain and discomfort. Acecarbromal works by blocking the transmission of pain signals in the nerves, providing temporary relief from discomfort. Its chemical structure consists of a benzoic acid group with an aminoethylcarboxylic group attached to the benzene ring, making it an effective and efficient pain reliever for various eye conditions. Overall, 2-[(1-carboxyethyl)amino]benzoic acid is an important chemical compound with pharmaceutical uses in the treatment of ocular pain.

Upstream product

• 118-92-3 anthranilic acid 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 552-37-4 sodium o-aminobenzoate 
• 302-72-7 rac-Ala-OH 
• 118-91-2 ortho-chlorobenzoic acid 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 75835-46-0 N-acetylphenylalanine-o-carboxylic acid 
• 23741-00-6 3-acetoxy-1-acetyl-2-methyl-1H-indole 
• 65881-18-7 1-Acetyl-2-methyl-3-oxo-2,3-dihydroindole 
• 4071-16-3 2-(2-methyl-1H-indol-3-yl)acetonitrile 

Relevant articles and documents

Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3′-biindoles

3,3′-Bisindoles are known to be important structural motifs found in bioactive natural products, pharmaceuticals, and functional materials. Herein, a novel indoxyl-based approach was established for the synthesis of unsymmetrical 3,3′-biindoles from indoles and indoxyls. This approach generated moderate to excellent yields of the desired products (24 examples, up to 98% yield). The present method features broad substrate scope, operational simplicity, high atom economy, and utilization of non-toxic and inexpensive molecular iodine as catalyst. The applicability of this method has been demonstrated by the facile gram-scale synthesis.

DOUBLE CYCLISATION OF PHENYLGLYCINE-o-CARBOXYLIC ACIDS - I NEW STABLE MESOIONIC OXAZOLONES

Remarkably stable mesoionic oxazolones possessing an oxazoloquinolinium structure (5a-b, 8, 16, 17) were obtained by the double cyclisation of phenylglycine-o-carboxylic acids (3a-c) in refluxing acetic anhydride or in benzoic anhydride at 140 deg.The O-Ac group was eliminated to give the corresponding lactones (6a-b) or replaced by O-Ts (7).IR stretching vibrations of the endo-carbonyl were in the range 1710-1768 cm-1, while ν1-CH exhibited unusually high values (3159-3194 cm-1). 1-Acyl derivatives could be obtained only with TFAA (23-24), although easydeuteration of the same position took place in the presence of traces of trifluoroacetic acid.Hydrolysis of 5b led to the α-quinolone-N-acetic acid 27a.In the case of 5a, hydrolysis was accompanied by self-acylation of the nucleophilic site at C-4 with formation of a dimeric acid 28a.The presence of an additional Me group in phenylalanine-o-carboxylic acid (36) activates the corresponding mesoionic oxazolone 37 so that 1-acylation becomes possible with formation of the fused oxazole 38 by the Dakin-West reaction.Temperature dependent magnetic non-equivalence of methylene protons has been observed in acids 3b-d and f and also in the 7-membered anhydride 48b.