227603-76-1

Basic information

• Product Name: 4-(benzyloxy)-2-bromobenzaldehyde
• CAS NO: 227603-76-1
• Molecular Weight: 291.144
• Mol File: 227603-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(benzyloxy)-2-bromobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(benzyloxy)-2-bromobenzaldehyde(227603-76-1)
• EPA Substance Registry System: 4-(benzyloxy)-2-bromobenzaldehyde(227603-76-1)

Safety Data

• Hazardous Substances Data: 227603-76-1(Hazardous Substances Data)

Downstream Products

• 879713-37-8 4-benzyloxy-2-tert-butylsulfanyl-benzaldehyde 
• 1226773-36-9 (5-(benzyloxy)-2-formylphenyl)boronic acid 
• 1425459-42-2 cyclohexylcarbamic acid 3′-carbamoyl-6-hydroxymethylbiphenyl-3-yl ester 
• 1446086-66-3 3-[5-benzyloxy-2-hydroxymethylphenyl]benzamide 
• 1446086-65-2 3-(5-benzyloxy-2-formylphenyl)benzamide 

Relevant articles and documents

Preparation method of aporphine alkaloid

The invention discloses a preparation method of aporphine alkaloid as shown in a formula III. The method comprises the following steps: taking a benzaldehyde compound as shown in a formula III-0 as a raw material, and sequentially carrying out Wittig reaction, Pictet-Spengler reaction, Heck reaction and palladium carbon hydrogen deprotection. A bromine-containing benzaldehyde derivative is selected as a raw material, the carbon-carbon coupling co-production rate and the reaction rate are increased through bromine atoms, and the reaction activity is improved; benzyl chloroformate is adopted for NH protection, and an electron withdrawing group is introduced, so that the reaction yield can be improved; and a styrene methyl ether derivative directly reacts with an acylated phenylethylamine derivative in an acid catalysis system by adopting a one-pot method so as to obtain benzyl tetrahydroisoquinoline. The preparation method has the advantages of mild reaction conditions, low toxicity of used reagents, easily available raw materials, convenient post-treatment and simpler reaction route compared with previous reports, and can be suitable for various reaction substrates.