22774-76-1

Basic information

• Product Name: Benzenamine, 4-bromo-N-2-propenyl-
• CAS NO: 22774-76-1
• Molecular Formula: C9H10BrN
• Molecular Weight: 212.089
• Mol File: 22774-76-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-bromo-N-2-propenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-bromo-N-2-propenyl-(22774-76-1)
• EPA Substance Registry System: Benzenamine, 4-bromo-N-2-propenyl-(22774-76-1)

Safety Data

• Hazardous Substances Data: 22774-76-1(Hazardous Substances Data)

Upstream product

• 589-09-3 N-allyl-N-phenylamine 
• 7575-57-7 allyl benzenesulfonate 
• 106-40-1 4-bromo-aniline 
• 106-95-6 allyl bromide 
• 107-18-6 allyl alcohol 
• 131818-17-2 tert-butyl (4-bromophenyl)carbamate 
• 1361121-45-0 C₁₄H₁₈BrNO₂ 

Downstream Products

• 1361121-53-0 C₁₆H₁₆BrNO₂S 
• 1361121-59-6 C₁₉H₁₈BrNO₂S 
• 1374693-98-7 C₂₇H₂₈BrNO₆S 
• 1533408-64-8 N-(2-allyl-4-bromophenyl)methanesulfonamide 
• 1610793-02-6 1-(4-bromophenyl)-3-methyleneazetidin-2-one 
• 500872-47-9 {(2-allyl-4-bromo-phenyl)-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-but-3-enoyl]-amino}-acetic acid tert-butyl ester 
• 500872-45-7 (2-allyl-4-bromo-phenylamino)-acetic acid tert-butyl ester 
• 99847-70-8 5-bromo-2-methyl-2,3-dihydroindole 
• 911294-84-3 N-(2-allyl-4-bromophenyl)benzamide 
• 106-40-1 4-bromo-aniline 
• 267002-57-3 2-allyl-4-bromoaniline 

Relevant articles and documents

Nickel-Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N-Containing Heterocyclic Compounds

A nickel-catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen-containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.

A Simple, Broad-Scope Nickel(0) Precatalyst System for the Direct Amination of Allyl Alcohols

The preparation of allylic amines is traditionally accomplished by reactions of amines with reactive electrophiles, such as allylic halides, sulfonates, or oxyphosphonium species; such methods involve hazardous reagents, generate stoichiometric waste streams, and often suffer from side reactions (such as overalkylation). We report here the first broad-scope nickel-catalysed direct amination of allyl alcohols: An inexpensive NiII/Zn couple enables the allylation of primary, secondary, and electron-deficient amines without the need for glove-box techniques. Under mild conditions, primary and secondary aliphatic amines react smoothly with a range of allyl alcohols, giving secondary and tertiary amines efficiently. This “totally catalytic” method can also be applied to electron-deficient nitrogen nucleophiles; the practicality of the process was demonstrated in an efficient, gram-scale preparation of the calcium antagonist drug substance flunarizine (Sibelium).

Efficient copper-catalyzed direct intramolecular aminotrifluoromethylation of unactivated alkenes with diverse nitrogen-based nucleophiles

A mild, convenient, and step-economical intramolecular aminotrifluoromethylation of unactivated alkenes with a variety of electronically distinct, nitrogen-based nucleophiles in the presence of a simple copper salt catalyst, in the absence of extra ligand