227751-94-2Relevant articles and documents
Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
Whitman, David B.,Askew, Ben C.,Duong, Le T.,Fernandez-Metzler, Carmen,Halczenko, Wasyl,Hartman, George D.,Hutchinson, John H.,Leu, Chih-Tai,Prueksaritanont, Thomayant,Rodan, Gideon A.,Rodan, Sevgi B.,Duggan, Mark E.
, p. 4411 - 4415 (2007/10/03)
A series of αvβ3 receptor antagonists lacking the amide bond of previously-reported 'chain-shortened' compounds is described. Replacement of the lone amide bond with two methylene groups in this series yields more lipophilic compound
