22779-86-8

Basic information

• Product Name: N-benzyl-N-cyclohexylformamide
• Synonyms: N-benzyl-N-cyclohexylformamide
• CAS NO: 22779-86-8
• Molecular Weight: 217.311
• Mol File: 22779-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-cyclohexylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-cyclohexylformamide(22779-86-8)
• EPA Substance Registry System: N-benzyl-N-cyclohexylformamide(22779-86-8)

Safety Data

• Hazardous Substances Data: 22779-86-8(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 108-91-8 cyclohexylamine 
• 4383-25-9 N-benzylcyclohexylamine 

Relevant articles and documents

Palladium-Catalyzed Solvent-Dependent Divergent Synthesis of Benzylformamides

A palladium-catalyzed carbonylative cascade procedure for the synthesis of benzylformamides from aryl halides has been developed. The properties of the solvent chosen play a decisive role on the selectivity of the outcomes. Non-coordinative solvent facilitates the coordination and insertion of CO to the amino-palladium intermediate which then provides the formamides products. While the use of coordinative solvent leads to the formation of amines. A series of functional groups, including ester, ketone, nitro and cyano, were well tolerated under our conditions. The corresponding benzylformamides products were prepared in moderate to good yields without further optimization. (Figure presented.).