22788-19-8 Usage
Description
Propylene Glycol Dilaurate is a clear, oily liquid at 20°C, which may appear colorless or slightly yellow. It is a synthetic ester derived from propylene glycol and lauric acid, commonly utilized in the pharmaceutical and cosmetic industries due to its emollient, solubilizing, and stabilizing properties.
Uses
Used in Pharmaceutical Industry:
Propylene Glycol Dilaurate is used as a surfactant for enhancing the stability and bioavailability of drugs. Its ability to reduce surface tension between oil and water phases allows for better dispersion and absorption of active pharmaceutical ingredients.
Used in Cosmetic Industry:
Propylene Glycol Dilaurate is used as an excipient in the formulation of cosmetics, particularly in creams, lotions, and ointments. It acts as an emollient, providing a smooth and soft texture to the skin, and also serves as a solubilizer for various cosmetic ingredients, ensuring their uniform distribution within the product.
Used in Lipid-based Drug Delivery Systems:
Propylene Glycol Dilaurate is used as a key component in the synthesis of lipid-based drug delivery systems. Its amphiphilic nature enables the formation of lipid nanoparticles or liposomes, which can encapsulate and protect drug molecules, improving their targeted delivery and controlled release.
Check Digit Verification of cas no
The CAS Registry Mumber 22788-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,7,8 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22788-19:
(7*2)+(6*2)+(5*7)+(4*8)+(3*8)+(2*1)+(1*9)=128
128 % 10 = 8
So 22788-19-8 is a valid CAS Registry Number.
InChI:InChI=1/C27H52O4/c1-4-6-8-10-12-14-16-18-20-22-26(28)30-24-25(3)31-27(29)23-21-19-17-15-13-11-9-7-5-2/h25H,4-24H2,1-3H3
22788-19-8Relevant articles and documents
Production of propylene glycol fatty acid monoesters by lipase-catalyzed reactions in organic solvents
Shaw,Shian
, p. 715 - 719 (2007/10/03)
Fatty acid monoesters of propylene glycol (1,2-propanediol) are good water-in-oil emulsifiers. These esters were synthesized enzymatically to overcome the problems associated with chemical processes. A Pseudomonas lipase was added to reaction mixtures containing propylene glycol and various acyl donors (fatty acids, fatty acid ethyl esters, fatty acid anhydrides and triglycerides) in organic solvents, and the mixtures were shaken at 30 °C. The products were analyzed by gas chromatography. The yield of monoesters was affected by the acyl donors, organic solvents, temperature, water content, pH memory and reaction time. The anhydrous (lyophilized) enzyme and fatty acid anhydrides were best for monoester production. The optimum pH ranges were 4-5 and 8-10. The yields of propylene glycol monolaurate, monomyristate, monopalmitate, monostearate and monooleate with 50 mM fatty acid anhydrides as acyl donors were 97.2, 79.6, 83.7, 89.7 and 93.4 mM, respectively; those with 50 mM fatty acids as acyl donors were 37.3, 28.7, 28.7, 35.3 and 36.2 mM, respectively. The yields of propylene glycol monopalmitate, monostearate and monooleate with 50 mM triglycerides as acyl donors were 87.4, 65.1 and 83.2 mM, respectively.
