227962-26-7

Basic information

• Product Name: (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
• Synonyms: (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester
• CAS NO: 227962-26-7
• Molecular Weight: 281.311
• Mol File: 227962-26-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester(227962-26-7)
• EPA Substance Registry System: (4S,5S)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester(227962-26-7)

Safety Data

• Hazardous Substances Data: 227962-26-7(Hazardous Substances Data)

Upstream product

• 195624-97-6 (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester 
• 60512-85-8 (E)-isopropyl cinnamate 
• 274681-89-9 (2R,3S)-3-benzoylamino-2-methanesulfonyloxy-3-phenylpropanoic acid methyl ester 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 

Downstream Products

• 442850-39-7 (2S,3S)-2-acetylthio-3-benzoylamino-3-phenylpropanoic acid methylamide 
• 235432-37-8 (4S,5S)-2,4-diphenyl-1,3-oxazoline-5-carboxylic acid 
• 442850-38-6 (4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxlic acid methylamide 

Relevant articles and documents

Preparation of β-amino-α-mercapto acids and amides: Stereocontrolled syntheses of 2′-sulfur analogues of the taxol C-13 side chain, both syn and anti S-acetyl-N-benzoyl-3-phenylisocysteine

Stereoselective syntheses of both syn and anti S-acetyl-N-benzoyl-3-phenylisocysteine as coupling-ready reagents via the ring-opening reactions of trans- and cis-oxazoline-5-carboxylates with thiolacetic acid were demonstrated. In addition, we report upon ring-opening reactions of oxazoline-5-carboxamides. Ab initio molecular calculations were used to explain the different reactivities of these oxazolines with respect to the ring-opening reaction.

A new semisynthesis of paclitaxel from Baccatin III

A new method for the semisynthesis of paclitaxel (Taxol) from baccatin III via a dioxo-oxathiazolidine intermediate is reported.