2280-42-4 Usage
Description
dl-3-Hydroxynorvaline is a non-proteinogenic amino acid derivative, which is norvaline (2-aminopentanoic acid) in which a hydrogen at position 3 is replaced by a hydroxy group.
Uses
Used in Pharmaceutical Industry:
dl-3-Hydroxynorvaline is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and properties.
Used in Research and Development:
dl-3-Hydroxynorvaline is utilized as a research compound in the field of biochemistry and medicinal chemistry. It serves as a valuable tool for studying the structure, function, and interactions of amino acids and their derivatives, as well as for developing new drugs and therapies.
Used in Cosmetic Industry:
dl-3-Hydroxynorvaline may be used as an active ingredient in cosmetic products for its potential skin benefits. Its unique structure could contribute to improved skin hydration, elasticity, and overall health.
Biochem/physiol Actions
3-Hydroxynorvaline (HNV) is a microbial, α amino acid threonine analogue which has antiviral activity (herpes virus) and is toxic to mammalian cells (embryotoxic and teratogenic) presumably via incorporation into proteins. 3-Hydroxynorvaline may be used as an unnatural amino acid to study the fidelity of protein translation at the level of acyl-tRNA editing. 3-Hydroxynorvaline may also be used to study enzymes and molecules involved in threonine metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 2280-42-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,8 and 0 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2280-42:
(6*2)+(5*2)+(4*8)+(3*0)+(2*4)+(1*2)=64
64 % 10 = 4
So 2280-42-4 is a valid CAS Registry Number.
2280-42-4Relevant articles and documents
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Potgieter,H.C. et al.
, p. 1757 - 1759 (1977)
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Modular solid-phase synthesis of teroxazoles as a class of α-helix mimetics
Pinto Gomes, Cristiano,Metz, Alexander,Bats, Jan W.,Gohlke, Holger,Goebel, Michael W.
supporting information; experimental part, p. 3270 - 3277 (2012/07/02)
α-Helices are ubiquitous structural elements of proteins and are important in molecular recognition. Small molecules mimicking α-helices have proven to be valuable biophysical probes or modulators of protein-protein interactions. Here, we present modeling studies and the modular solid-phase synthesis of teroxazole derivatives as a new class of α-helix mimetics. The synthesis is compatible with a variety of functional groups and should thus be generally applicable for generating diversely substituted oligo-oxazole scaffolds. The teroxazole scaffold is predicted to be polar and to project peptidomimetic side chains at positions i, i+3, and i+6 of an α-helix, which complements projection patterns of existing helix mimetics. The scaffold retains sufficient conformational flexibility to conform to induced-fit models of protein-protein interaction inhibition. Copyright
Synthesis of aliphatic 2-amino-3-hydroxy acids and separation of their diastereoisomers with the aid of copper chelates.
MIX
, p. 41 - 48 (2007/10/06)
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